| pubmed-article:815252 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:815252 | lifeskim:mentions | umls-concept:C0004595 | lld:lifeskim |
| pubmed-article:815252 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:815252 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:815252 | lifeskim:mentions | umls-concept:C0055330 | lld:lifeskim |
| pubmed-article:815252 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:815252 | pubmed:dateCreated | 1976-6-2 | lld:pubmed |
| pubmed-article:815252 | pubmed:abstractText | The lesions induced in Bacillus subtilis deoxyribonucleic acid (DNA) after treating bacterial cells (in vivo) and bacterial DNA (in vitro) with chloramine were studied biologically and physically. Single-strand breaks and a few double-strand scissions (at higher chloramine doses) accompanied loss of DNA-transforming activity in both kinds of treatments. Chloramine was about three times more efficient in vitro than in vivo in inducing DNA single-strand breaks. DNA was slowly chlorinated; the subsequent efficiency of producing DNA breaks was high. Chlorination of cells also reduced activity of endonucleases in cells; however, chlorinated DNA of both treatments was sensitized to cleavage by endonucleases. The procedure of extracting DNA from cells treated with chloramine induced further DNA degradation. Both treatments introduced a small fraction of alkali-sensitive lesions in DNA. DNA chlorinated in vitro showed further reduction in transforming activity as well as further degradation after incubation at 50 C for 5 h whereas DNA extracted from chloramine-treated cells did not show such a heat sensitivity. | lld:pubmed |
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| pubmed-article:815252 | pubmed:language | eng | lld:pubmed |
| pubmed-article:815252 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:815252 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:815252 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:815252 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:815252 | pubmed:issn | 0021-9193 | lld:pubmed |
| pubmed-article:815252 | pubmed:author | pubmed-author:LederbergJJ | lld:pubmed |
| pubmed-article:815252 | pubmed:author | pubmed-author:Lu ShihKK | lld:pubmed |
| pubmed-article:815252 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:815252 | pubmed:volume | 125 | lld:pubmed |
| pubmed-article:815252 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:815252 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:815252 | pubmed:pagination | 934-45 | lld:pubmed |
| pubmed-article:815252 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:815252 | pubmed:year | 1976 | lld:pubmed |
| pubmed-article:815252 | pubmed:articleTitle | Effects of chloramine on Bacillus subtilis deoxyribonucleic acid. | lld:pubmed |
| pubmed-article:815252 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:815252 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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