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Predicate | Object |
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rdf:type | |
lifeskim:mentions |
umls-concept:C0016904,
umls-concept:C0019564,
umls-concept:C0028263,
umls-concept:C0030685,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0243144,
umls-concept:C0391871,
umls-concept:C0392747,
umls-concept:C0441513,
umls-concept:C0680255,
umls-concept:C1283071,
umls-concept:C1519355,
umls-concept:C1527177,
umls-concept:C1963578
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pubmed:issue |
12
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pubmed:dateCreated |
1994-5-10
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pubmed:abstractText |
The effects of exposure to chronic noise and vibration, produced by construction work, on the release and uptake of [3H]5-hydroxytryptamine ([3H]5-HT) and [14C]gamma-aminobutyric acid ([14C]GABA) from rat amygdaloid and hippocampal slices were investigated. Noise-exposure resulted in increased release, with no significant change in uptake, of [14C]GABA from amygdaloid slices. In hippocampal slices, [14C]GABA release was also increased, but the changes in release were dependent upon the marked decrease in uptake of [14C]GABA into these slices. There was an increase in peak K(+)-evoked release of [3H]5-HT from hippocampal slices, but no other changes in [3H]5-HT release or uptake in either region were observed following noise-exposure. These findings may have important practical implications for the research carried out in laboratories exposed to construction noise and vibrations.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0028-3908
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1333-6
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pubmed:dateRevised |
2009-9-29
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pubmed:meshHeading |
pubmed-meshheading:8152524-Amygdala,
pubmed-meshheading:8152524-Animals,
pubmed-meshheading:8152524-Biological Transport,
pubmed-meshheading:8152524-Carbon Radioisotopes,
pubmed-meshheading:8152524-Environmental Exposure,
pubmed-meshheading:8152524-Hippocampus,
pubmed-meshheading:8152524-Male,
pubmed-meshheading:8152524-Noise,
pubmed-meshheading:8152524-Organ Specificity,
pubmed-meshheading:8152524-Potassium,
pubmed-meshheading:8152524-Rats,
pubmed-meshheading:8152524-Rats, Inbred Strains,
pubmed-meshheading:8152524-gamma-Aminobutyric Acid
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pubmed:year |
1993
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pubmed:articleTitle |
Beware the builders: construction noise changes [14C]GABA release and uptake from amygdaloid and hippocampal slices in the rat.
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pubmed:affiliation |
Psychopharmacology Research Unit, UMDS Division of Pharmacology, Guy's Hospital, London, U.K.
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pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro,
Research Support, Non-U.S. Gov't
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