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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6473
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pubmed:dateCreated |
1994-5-9
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pubmed:abstractText |
The endothelin-1 (ET-1) gene was disrupted in mouse embryonic stem cells by homologous recombination to generate mice deficient in ET-1. These ET-1-/- homozygous mice die of respiratory failure at birth and have morphological abnormalities of the pharyngeal-arch-derived craniofacial tissues and organs. ET-1+/- heterozygous mice, which produce lower levels of ET-1 than wild-type mice, develop elevated blood pressure. These results suggest that ET-1 is essential for normal mouse development and may also play a physiological role in cardiovascular homeostasis.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0028-0836
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
368
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pubmed:geneSymbol |
ET-1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
N
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pubmed:pagination |
703-10
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8152482-Animals,
pubmed-meshheading:8152482-Base Sequence,
pubmed-meshheading:8152482-Blood Pressure,
pubmed-meshheading:8152482-Branchial Region,
pubmed-meshheading:8152482-DNA Primers,
pubmed-meshheading:8152482-Embryonic and Fetal Development,
pubmed-meshheading:8152482-Endothelins,
pubmed-meshheading:8152482-Female,
pubmed-meshheading:8152482-Heterozygote,
pubmed-meshheading:8152482-Homozygote,
pubmed-meshheading:8152482-Male,
pubmed-meshheading:8152482-Mice,
pubmed-meshheading:8152482-Mice, Inbred C57BL,
pubmed-meshheading:8152482-Mice, Inbred ICR,
pubmed-meshheading:8152482-Molecular Sequence Data,
pubmed-meshheading:8152482-Organ Culture Techniques,
pubmed-meshheading:8152482-Respiratory Insufficiency,
pubmed-meshheading:8152482-Skull,
pubmed-meshheading:8152482-Stem Cells
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pubmed:year |
1994
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pubmed:articleTitle |
Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1.
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pubmed:affiliation |
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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