rdf:type |
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lifeskim:mentions |
|
pubmed:issue |
6
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pubmed:dateCreated |
1994-5-11
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pubmed:abstractText |
The localization of mRNA encoding recoverin in the human retina was examined by in situ hybridization. The riboprobe utilized in this study was transcribed from a cDNA clone containing the complete coding region of human recoverin. The riboprobe hybridized extensively with the photoreceptor inner segments, and the outer nuclear layer. Specific hybridization was also seen in a subpopulation of cells in the inner nuclear layer, and occasionally in cells of the ganglion cell layer (GCL). Recoverin-like immunoreactivity was observed in all photoreceptors, and in a subpopulation of bipolar cells. Very robust immunolabeling was observed in a small population of cells in the GCL. This study suggests that recoverin, or a recoverin-like protein, is produced by at least three different cell types in the human retina: photoreceptors, bipolars and rare cells in the ganglion cell layer.
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pubmed:grant |
|
pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Dec
|
pubmed:issn |
0014-4835
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
57
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
763-9
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:8150028-Adult,
pubmed-meshheading:8150028-Calcium-Binding Proteins,
pubmed-meshheading:8150028-Eye Proteins,
pubmed-meshheading:8150028-Gene Expression,
pubmed-meshheading:8150028-Hippocalcin,
pubmed-meshheading:8150028-Humans,
pubmed-meshheading:8150028-In Situ Hybridization,
pubmed-meshheading:8150028-Lens Nucleus, Crystalline,
pubmed-meshheading:8150028-Lipoproteins,
pubmed-meshheading:8150028-Male,
pubmed-meshheading:8150028-Nerve Tissue Proteins,
pubmed-meshheading:8150028-RNA, Messenger,
pubmed-meshheading:8150028-Recoverin,
pubmed-meshheading:8150028-Retina,
pubmed-meshheading:8150028-Retinal Rod Photoreceptor Cells
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pubmed:year |
1993
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pubmed:articleTitle |
Expression of recoverin mRNA in the human retina: localization by in situ hybridization.
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pubmed:affiliation |
Department of Neurobiology and Anatomy, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|