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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
1994-5-6
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pubmed:abstractText |
A glucan (AG-HN1, [alpha]D +24 degrees) and a heteroglycan (AG-HN2, [alpha]D +26 degrees) were isolated from a hot-water extract of the fruiting bodies of Agrocybe cylindracea. The structures were investigated by a combination of chemical and spectroscopic methods. The results indicated that high molecular weight glucan AG-HN1 is primarily a beta-(1-->6)-branched (1-->3)-beta-D-glucan containing small amounts of (1-->4)-linked and (1-->6)-linked glucopyranosyl residues. Low molecular weight heteroglycan AG-HN2 gives galactose, glucose, fucose, and mannose on hydrolysis and appears to be chiefly composed of (1-->6)-linked gluco- and galacto-pyranosyl residues, many of them branched, and various nonreducing terminal residues. AG-HN1 showed a remarkable hypoglycemic activity in both normal and streptozotocin-induced diabetic mice by ip administration, and its activity was higher than that of AG-HN2.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoglycemic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Polysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Streptozocin,
http://linkedlifedata.com/resource/pubmed/chemical/Tissue Extracts
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0008-6215
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
251
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
81-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8149381-Animals,
pubmed-meshheading:8149381-Basidiomycota,
pubmed-meshheading:8149381-Blood Glucose,
pubmed-meshheading:8149381-Diabetes Mellitus, Experimental,
pubmed-meshheading:8149381-Hypoglycemic Agents,
pubmed-meshheading:8149381-Male,
pubmed-meshheading:8149381-Mice,
pubmed-meshheading:8149381-Mice, Inbred Strains,
pubmed-meshheading:8149381-Polysaccharides,
pubmed-meshheading:8149381-Streptozocin,
pubmed-meshheading:8149381-Tissue Extracts
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pubmed:year |
1994
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pubmed:articleTitle |
Structural features and hypoglycemic activities of two polysaccharides from a hot-water extract of Agrocybe cylindracea.
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pubmed:affiliation |
Gifu Pharmaceutical University, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study
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