Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
1994-5-6
pubmed:abstractText
This study investigated whether the growth of transplanted mammary tumors is altered in rats by treatment with the antimalarial drugs chloroquine (CQ) and quinacrine (QN). Female inbred F344 rats were divided into three experimental groups. Animals were injected i.p. with either CQ, QN or normal saline for 5 days a week throughout the entire experimental period (25 days). After 7 days of drug treatment each rat received subcutaneously one 2-mm2 aliquot of R3230AC mammary adenocarcinoma in the mid-thoracic region. Eighteen days after implantation, all rats were sacrificed and tumors were excised, weighed and measured. The results indicate that weights and volumes of tumors as well as tumor-to-body weight ratios were significantly higher in CQ and QN-treated animals than those in saline-treated animals. The final body weights of rats treated with QN were significantly lower than those treated with saline. The prostaglandin E2 content of tumors was significantly reduced by CQ treatment. Erythrocyte glutathione reductase activity coefficient and reduced glutathione concentrations remained unaffected by both treatments. These results suggest that CQ and QN have significant stimulatory effects on the growth of mammary adenocarcinoma in rats.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0304-3835
pubmed:author
pubmed:issnType
Print
pubmed:day
30
pubmed:volume
76
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
113-9
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:8149339-Adenocarcinoma, pubmed-meshheading:8149339-Animals, pubmed-meshheading:8149339-Body Weight, pubmed-meshheading:8149339-Cell Division, pubmed-meshheading:8149339-Chloroquine, pubmed-meshheading:8149339-Dinoprostone, pubmed-meshheading:8149339-Erythrocytes, pubmed-meshheading:8149339-Female, pubmed-meshheading:8149339-Glutathione, pubmed-meshheading:8149339-Mammary Neoplasms, Experimental, pubmed-meshheading:8149339-Neoplasm Transplantation, pubmed-meshheading:8149339-Oxygen, pubmed-meshheading:8149339-Quinacrine, pubmed-meshheading:8149339-Rats, pubmed-meshheading:8149339-Rats, Inbred F344, pubmed-meshheading:8149339-Riboflavin, pubmed-meshheading:8149339-Riboflavin Deficiency, pubmed-meshheading:8149339-Stimulation, Chemical, pubmed-meshheading:8149339-Stress, Physiological
pubmed:year
1994
pubmed:articleTitle
Enhanced growth of mammary adenocarcinoma in rats by chloroquine and quinacrine.
pubmed:affiliation
Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't