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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1976-4-10
|
| pubmed:abstractText |
One unit (500 ml) of 10% Intralipid (an intravenous soy bean oil-egg yolk lecithin preparation) was infused into 20 normal subjects over 4 hr. Serum triglyceride concentration and plasma optic density (at 700 nm) increased to maximal levels of 339 +/- 102 mg/100 ml and 1.14 +/- 0.41, respectively, at the completion of the infusion, and returned to basal levels in most subjects within 4 hr. Pulmonary membrane diffusion was decreased in six subjects at rest and with exercise at 25 and 50% maximum oxygen uptake. Only one subject showed a minor change in PO2 and none showed clinical signs of ischemia. The changes in pulmonary diffusion reverted to basal levels when serum lipids were cleared. Heparin (60 IU/kg) prevented the marked increase in serum lipids and, as a consequence, the changes in pulmonary function. Changes in pulmonary function from Intralipid-induced lipemia are similar to those known to result from diet-induced lipemia. The findings suggest that in the presence of normal vasculature and pulmonary function, Intralipid-induced lipemia should cause no clinical consequences. However, patients with preexisting pulmonary or vascular disease may be at greater risk after Intralipid-induced lipemia.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carbon Monoxide,
http://linkedlifedata.com/resource/pubmed/chemical/Lipids,
http://linkedlifedata.com/resource/pubmed/chemical/Oils,
http://linkedlifedata.com/resource/pubmed/chemical/Oxygen,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylcholines,
http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0002-9165
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
29
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
127-35
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:814803-Adult,
pubmed-meshheading:814803-Animals,
pubmed-meshheading:814803-Blood,
pubmed-meshheading:814803-Carbon Monoxide,
pubmed-meshheading:814803-Egg Yolk,
pubmed-meshheading:814803-Female,
pubmed-meshheading:814803-Humans,
pubmed-meshheading:814803-Hyperlipidemias,
pubmed-meshheading:814803-Lipids,
pubmed-meshheading:814803-Liver,
pubmed-meshheading:814803-Lung,
pubmed-meshheading:814803-Nephelometry and Turbidimetry,
pubmed-meshheading:814803-Oils,
pubmed-meshheading:814803-Oxygen,
pubmed-meshheading:814803-Oxygen Consumption,
pubmed-meshheading:814803-Parenteral Nutrition,
pubmed-meshheading:814803-Phosphatidylcholines,
pubmed-meshheading:814803-Pulmonary Diffusing Capacity,
pubmed-meshheading:814803-Rabbits,
pubmed-meshheading:814803-Soybeans,
pubmed-meshheading:814803-Triglycerides
|
| pubmed:year |
1976
|
| pubmed:articleTitle |
Relationship between Intralipid-induced hyperlipemia and pulmonary function.
|
| pubmed:publicationType |
Journal Article
|