| pubmed-article:8146320 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8146320 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:8146320 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:8146320 | lifeskim:mentions | umls-concept:C0025920 | lld:lifeskim |
| pubmed-article:8146320 | lifeskim:mentions | umls-concept:C0920487 | lld:lifeskim |
| pubmed-article:8146320 | lifeskim:mentions | umls-concept:C0007621 | lld:lifeskim |
| pubmed-article:8146320 | lifeskim:mentions | umls-concept:C0026004 | lld:lifeskim |
| pubmed-article:8146320 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:8146320 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:8146320 | lifeskim:mentions | umls-concept:C1545588 | lld:lifeskim |
| pubmed-article:8146320 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:8146320 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:8146320 | lifeskim:mentions | umls-concept:C1522492 | lld:lifeskim |
| pubmed-article:8146320 | pubmed:issue | 1 Suppl | lld:pubmed |
| pubmed-article:8146320 | pubmed:dateCreated | 1994-5-5 | lld:pubmed |
| pubmed-article:8146320 | pubmed:abstractText | We have monitored the end points of cellular survival, micronucleus formation and neoplastic transformation frequency to assess adaptation to ionizing radiation in the C3H 10T1/2 mouse embryo cell system. Plateau-phase cells were pre-exposed to an adapting dose of 0.1 to 1.5 Gy low-dose-rate gamma radiation 3.5 h prior to an acute challenge dose of 4 Gy. No adapting dose improved clonogenic survival detectably, whether the cells were plated immediately after the acute exposure or held in plateau phase for 3.5 h before plating. However, all chronic adapting doses resulted in both a reduction in micronucleus frequency in binucleate cells and about a twofold reduction in neoplastic transformation frequency per viable cell when cells were subsequently exposed to the 4-Gy challenge dose. Our data suggest that a low-dose-rate pre-exposure to ionizing radiation induces an adaptive response in C3H 10T1/2 cells, and that this response enhances DNA double-strand break repair when cells are subsequently exposed to a second radiation dose. This enhanced repair appears to be error-free since these adapted cells are also less susceptible to radiation-induced neoplastic transformation. | lld:pubmed |
| pubmed-article:8146320 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8146320 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8146320 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8146320 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8146320 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:8146320 | pubmed:issn | 0033-7587 | lld:pubmed |
| pubmed-article:8146320 | pubmed:author | pubmed-author:MitchelR ERE | lld:pubmed |
| pubmed-article:8146320 | pubmed:author | pubmed-author:RaaphorstG... | lld:pubmed |
| pubmed-article:8146320 | pubmed:author | pubmed-author:AzzamE IEI | lld:pubmed |
| pubmed-article:8146320 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8146320 | pubmed:volume | 138 | lld:pubmed |
| pubmed-article:8146320 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8146320 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8146320 | pubmed:pagination | S28-31 | lld:pubmed |
| pubmed-article:8146320 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:8146320 | pubmed:meshHeading | pubmed-meshheading:8146320-... | lld:pubmed |
| pubmed-article:8146320 | pubmed:meshHeading | pubmed-meshheading:8146320-... | lld:pubmed |
| pubmed-article:8146320 | pubmed:meshHeading | pubmed-meshheading:8146320-... | lld:pubmed |
| pubmed-article:8146320 | pubmed:meshHeading | pubmed-meshheading:8146320-... | lld:pubmed |
| pubmed-article:8146320 | pubmed:meshHeading | pubmed-meshheading:8146320-... | lld:pubmed |
| pubmed-article:8146320 | pubmed:meshHeading | pubmed-meshheading:8146320-... | lld:pubmed |
| pubmed-article:8146320 | pubmed:meshHeading | pubmed-meshheading:8146320-... | lld:pubmed |
| pubmed-article:8146320 | pubmed:meshHeading | pubmed-meshheading:8146320-... | lld:pubmed |
| pubmed-article:8146320 | pubmed:meshHeading | pubmed-meshheading:8146320-... | lld:pubmed |
| pubmed-article:8146320 | pubmed:meshHeading | pubmed-meshheading:8146320-... | lld:pubmed |
| pubmed-article:8146320 | pubmed:meshHeading | pubmed-meshheading:8146320-... | lld:pubmed |
| pubmed-article:8146320 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8146320 | pubmed:articleTitle | Radiation-induced adaptive response for protection against micronucleus formation and neoplastic transformation in C3H 10T1/2 mouse embryo cells. | lld:pubmed |
| pubmed-article:8146320 | pubmed:affiliation | Radiation Biology Branch, Chalk River Laboratories, Ontario, Canada. | lld:pubmed |
| pubmed-article:8146320 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8146320 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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