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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1994-5-5
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pubmed:databankReference |
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pubmed:abstractText |
Disintegrins are short soluble integrin ligands that were initially identified in snake venom. A previously recognized cellular protein with a disintegrin domain was the guinea pig sperm protein PH-30, a protein implicated in sperm-egg membrane binding and fusion. Here we present peptide sequences that are characteristic for several cellular disintegrin-domain proteins. These peptide sequences were deduced from cDNA sequence tags that were generated by polymerase chain reaction from various mouse tissue and a mouse muscle cell line. Northern blot analysis with four sequence tags revealed distinct mRNA expression patterns. Evidently, cellular proteins containing a disintegrin domain define a superfamily of potential integrin ligands that are likely to function in important cell-cell and cell-matrix interactions.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8146185-1378300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8146185-1417724,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8146185-1419054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8146185-1439803,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8146185-1552944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8146185-1555235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8146185-1629211,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8146185-1717161,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8146185-1755841,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8146185-1931079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8146185-1974032,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8146185-1982220,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8146185-2114412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8146185-2236100,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8146185-2320569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8146185-2364514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8146185-2398046,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8146185-2440339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8146185-2600082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8146185-2653425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8146185-3680247,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8146185-3793758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8146185-563524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8146185-6326095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8146185-7691492,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8146185-8223430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8146185-8240823,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8146185-8252040,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8146185-8330674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8146185-8419314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8146185-8419912
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
29
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pubmed:volume |
91
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2748-51
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8146185-ADAM Proteins,
pubmed-meshheading:8146185-Amino Acid Sequence,
pubmed-meshheading:8146185-Animals,
pubmed-meshheading:8146185-Consensus Sequence,
pubmed-meshheading:8146185-Disintegrins,
pubmed-meshheading:8146185-Male,
pubmed-meshheading:8146185-Membrane Glycoproteins,
pubmed-meshheading:8146185-Metalloendopeptidases,
pubmed-meshheading:8146185-Mice,
pubmed-meshheading:8146185-Mice, Inbred BALB C,
pubmed-meshheading:8146185-Molecular Sequence Data,
pubmed-meshheading:8146185-Multigene Family,
pubmed-meshheading:8146185-Peptides,
pubmed-meshheading:8146185-RNA, Messenger,
pubmed-meshheading:8146185-Sequence Homology, Amino Acid,
pubmed-meshheading:8146185-Tissue Distribution,
pubmed-meshheading:8146185-Venoms
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pubmed:year |
1994
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pubmed:articleTitle |
A family of cellular proteins related to snake venom disintegrins.
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pubmed:affiliation |
Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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