Linked Life Data

8144493

Source:http://linkedlifedata.com/resource/pubmed/id/8144493

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1994-5-5
pubmed:abstractText
Na+/H+ antiporters are universal devices involved in the Na+ and H+ circulation of both eukaryotes and prokaryotes, thus playing an essential role in the pH and Na+ homeostasis of cells. This review focuses on the major impact of the application of molecular biology tools in the study of the antiporters. These tools permit the verification of the role of the antiporters and provide insights into their unique biology. A novel signal transduction to Na+ involving nhaR, a positive regulator, controls the expression of nhaA in E. coli. A "pH sensor" regulates the activity of Na+/H+ antiporters, both in eukaryotes and prokaryotes. A most intricate signal transduction to pH involving phosphorylation steps controls the activity of nhel in higher mammals. The identification of Histidine 226 in the "pH sensor" of NhaA is a step forward towards the understanding of the pH regulation of these proteins.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0145-479X
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:geneSymbol
&bgr;nhe, cadB, cadC, chaA, napA, nhaA, nhaB, nhaC, nhaR, nhaS, nhe2, nhe4, sod2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
647-69
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Na+/H+ antiporters, molecular devices that couple the Na+ and H+ circulation in cells.
pubmed:affiliation
Division of Microbial and Molecular Ecology, Hebrew University of Jerusalem, Israel.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, Non-P.H.S., Review, Research Support, Non-U.S. Gov't