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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1994-5-3
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pubmed:abstractText |
Three human neuroblastoma cell lines were examined to determine the effect of recombinant gamma-interferon (IFN-gamma) treatment on the expression of trk proto-oncogene. Increased levels of trk proto-oncogene mRNA were observed in two neuroblastoma cell lines (KP-N-RT and KP-N-SI(FA)) after IFN-gamma treatment. The levels of trk mRNA increased with growth inhibition and morphological change in a time- and dose-dependent manner. The decreased level of N-myc mRNA after IFN-gamma treatment in KP-N-RT was inversely correlated with trk mRNA. Our results suggest that IFN-gamma can modulate the signal transduction of nerve growth factor in human neuroblastoma cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0910-5050
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
85
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pubmed:geneSymbol |
N-myc,
trk
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
122-6
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:8144393-Blotting, Northern,
pubmed-meshheading:8144393-Dose-Response Relationship, Drug,
pubmed-meshheading:8144393-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:8144393-Genes, myc,
pubmed-meshheading:8144393-Humans,
pubmed-meshheading:8144393-Interferon-gamma,
pubmed-meshheading:8144393-Nerve Growth Factors,
pubmed-meshheading:8144393-Neuroblastoma,
pubmed-meshheading:8144393-Oncogene Proteins,
pubmed-meshheading:8144393-Proto-Oncogenes,
pubmed-meshheading:8144393-RNA, Messenger,
pubmed-meshheading:8144393-RNA, Neoplasm,
pubmed-meshheading:8144393-Signal Transduction,
pubmed-meshheading:8144393-Tumor Cells, Cultured
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pubmed:year |
1994
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pubmed:articleTitle |
Increased expression of trk proto-oncogene by gamma-interferon in human neuroblastoma cell lines.
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pubmed:affiliation |
Department of Pediatrics, Kyoto Prefectural University of Medicine, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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