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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1994-5-5
|
| pubmed:abstractText |
Inositol 1,4,5-trisphosphate (InsP3)-induced Ca2+ release depends on the cytoplasmic concentration of Ca2+ in a biphasic manner: activated with the increase in Ca2+ up to approximately 300 nM and inhibited by its further increase. Kinetic studies of the Ca2+ release with rapid increase in Ca2+ or InsP3 using respective caged compounds indicated that the effects of Ca2+ appear immediately upon change in the Ca2+ concentration. Recovery from the Ca(2+)-dependent inhibition seemed also rapid after reduction in the Ca2+ concentration. These results indicate that there is a Ca(2+)-mediated positive feedback control of InsP3-induced Ca2+ release below 300 nM Ca2+. This feedback control seems to explain, at least partly, the phenomenon that InsP3 is more effective in the Ca2+ stores with greater Ca2+ loading. The Ca(2+)-mediated feedback control is also expected to give rise to temporally or spatially confined Ca2+ release as well as Ca2+ wave within the cells.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0303-7207
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
98
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
141-6
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading | |
| pubmed:year |
1994
|
| pubmed:articleTitle |
Feedback control of inositol trisphosphate signalling bycalcium.
|
| pubmed:affiliation |
Department of Pharmacology, Faculty of Medicine, University of Tokyo, Japan.
|
| pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
|