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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1994-5-5
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pubmed:databankReference |
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pubmed:abstractText |
Tau protein kinase II (TPKII) was reported previously to be composed of a neuron-rich cdc2-related kinase (PSSALRE/cdk5) and 23 kDa subunit. Here we show that the 23 kDa subunit is a putative activator for the kinase activity. Amino acid sequence analysis revealed that the protein was novel and included a partial similarity of amino acids to a cyclin box important for the interaction with cdc2-related kinase. These results suggest that the 23 kDa subunit, but not cyclin, activates cdk5 in neuronal cells, which no longer exhibit cell cycling but are terminally differentiated cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CDK5 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase 5,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Probes,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/tau protein kinase II
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
4
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pubmed:volume |
342
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
203-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:8143878-Amino Acid Sequence,
pubmed-meshheading:8143878-Animals,
pubmed-meshheading:8143878-Base Sequence,
pubmed-meshheading:8143878-Brain,
pubmed-meshheading:8143878-Cattle,
pubmed-meshheading:8143878-Cyclin-Dependent Kinase 5,
pubmed-meshheading:8143878-Cyclin-Dependent Kinases,
pubmed-meshheading:8143878-Cyclins,
pubmed-meshheading:8143878-DNA, Complementary,
pubmed-meshheading:8143878-DNA Primers,
pubmed-meshheading:8143878-DNA Probes,
pubmed-meshheading:8143878-Enzyme Activation,
pubmed-meshheading:8143878-Humans,
pubmed-meshheading:8143878-Molecular Sequence Data,
pubmed-meshheading:8143878-Molecular Weight,
pubmed-meshheading:8143878-Peptide Fragments,
pubmed-meshheading:8143878-Protein Conformation,
pubmed-meshheading:8143878-Protein Kinases,
pubmed-meshheading:8143878-Protein-Serine-Threonine Kinases,
pubmed-meshheading:8143878-Sequence Homology, Amino Acid
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pubmed:year |
1994
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pubmed:articleTitle |
Identification of the 23 kDa subunit of tau protein kinase II as a putative activator of cdk5 in bovine brain.
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pubmed:affiliation |
Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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