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rdf:type |
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lifeskim:mentions |
umls-concept:C0005821,
umls-concept:C0021554,
umls-concept:C0028778,
umls-concept:C0086418,
umls-concept:C0123263,
umls-concept:C0332206,
umls-concept:C0332281,
umls-concept:C0597357,
umls-concept:C1268567,
umls-concept:C1519726,
umls-concept:C1522492,
umls-concept:C1948023,
umls-concept:C2757011
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pubmed:issue |
1
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pubmed:dateCreated |
1994-5-3
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pubmed:abstractText |
We report that activation of phospholipase C (PLC) by cross-linking of the platelet low-affinity Fc gamma receptor II (Fc gamma RII) is inhibited by two structurally distinct tyrosine kinase inhibitors, staurosporine and ST271. This contrasts with PLC activation induced by thrombin and U46619, a thromboxane mimetic, whose receptors have seven transmembrane domains characteristic of G-protein coupled receptors. Several proteins undergo phosphorylation on tyrosine on Fc gamma RII cross-linking upstream of protein kinase C (PKC), Ca2+ and aggregation, including the Fc gamma RII itself. The role of Fc gamma RII phosphorylation in the regulation of PLC is discussed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1,2-bis(2-aminophenoxy)ethane...,
http://linkedlifedata.com/resource/pubmed/chemical/15-Hydroxy-11 alpha,9...,
http://linkedlifedata.com/resource/pubmed/chemical/Alkaloids,
http://linkedlifedata.com/resource/pubmed/chemical/Egtazic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Indoles,
http://linkedlifedata.com/resource/pubmed/chemical/Inositol Phosphates,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin Endoperoxides...,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, IgG,
http://linkedlifedata.com/resource/pubmed/chemical/Ro 31-8220,
http://linkedlifedata.com/resource/pubmed/chemical/Staurosporine,
http://linkedlifedata.com/resource/pubmed/chemical/Styrenes,
http://linkedlifedata.com/resource/pubmed/chemical/Thrombin,
http://linkedlifedata.com/resource/pubmed/chemical/Thromboxane A2,
http://linkedlifedata.com/resource/pubmed/chemical/Type C Phospholipases,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
28
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pubmed:volume |
342
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
15-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:8143842-15-Hydroxy-11 alpha,9...,
pubmed-meshheading:8143842-Alkaloids,
pubmed-meshheading:8143842-Blood Platelets,
pubmed-meshheading:8143842-Egtazic Acid,
pubmed-meshheading:8143842-Humans,
pubmed-meshheading:8143842-Indoles,
pubmed-meshheading:8143842-Inositol Phosphates,
pubmed-meshheading:8143842-Phosphorylation,
pubmed-meshheading:8143842-Prostaglandin Endoperoxides, Synthetic,
pubmed-meshheading:8143842-Protein Kinase C,
pubmed-meshheading:8143842-Protein-Tyrosine Kinases,
pubmed-meshheading:8143842-Receptors, IgG,
pubmed-meshheading:8143842-Staurosporine,
pubmed-meshheading:8143842-Styrenes,
pubmed-meshheading:8143842-Thrombin,
pubmed-meshheading:8143842-Thromboxane A2,
pubmed-meshheading:8143842-Type C Phospholipases,
pubmed-meshheading:8143842-Tyrosine
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pubmed:year |
1994
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pubmed:articleTitle |
Fc gamma receptor II stimulated formation of inositol phosphates in human platelets is blocked by tyrosine kinase inhibitors and associated with tyrosine phosphorylation of the receptor.
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pubmed:affiliation |
Department of Biochemistry, University of Dundee, Scotland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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