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Predicate | Object |
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rdf:type | |
lifeskim:mentions |
umls-concept:C0019868,
umls-concept:C0022702,
umls-concept:C0023401,
umls-concept:C0028158,
umls-concept:C0030011,
umls-concept:C0086418,
umls-concept:C0205081,
umls-concept:C0221102,
umls-concept:C0301630,
umls-concept:C0332169,
umls-concept:C0392747,
umls-concept:C0443172,
umls-concept:C0444584,
umls-concept:C0489617
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pubmed:issue |
2
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pubmed:dateCreated |
1994-5-4
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pubmed:abstractText |
1. The adaptation of the diurnal cycle of nitrogen (N) homeostasis during a change in protein intake was investigated with diurnal measurements of N and leucine balance and turnover during a reduction from a high to a moderate protein intake in normal adults. 2. In experiment 1, during a 9 day period after a reduction from 1.82 to 0.77 g of protein day-1 kg-1, N excretion fell slowly at a similar rate in fed and fasted states so that the lowered intake was unable to replete any of the postabsorptive losses for 3 days. There was a marked negative N balance, which persisted throughout the study, although with a significant reduction in N losses in both fed and fasted states on day 4, balances during days 4-9 (-32.8 +/- 28.3 mg of N day-1 kg-1) were less negative than during days 1-3 (-79.1 +/- 60.4 mg of N day-1 kg-1). 3. In experiment 2, during a 14 day period after a reduction from 1.89 to 0.77 g of protein day-1 kg-1, [1-13C]leucine oxidation and turnover were measured by primed intravenous infusion, during fasting and feeding in subjects before and on days 3, 7 and 14 after the dietary change. Leucine oxidation fell by 32% (P < 0.05) on day 3 in the fed state and by 12% (P < 0.05) during fasting, falling further in each case by day 7 with improved balance.(ABSTRACT TRUNCATED AT 250 WORDS)
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0143-5221
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
86
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
185-93
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8143429-Adaptation, Physiological,
pubmed-meshheading:8143429-Adult,
pubmed-meshheading:8143429-Circadian Rhythm,
pubmed-meshheading:8143429-Dietary Proteins,
pubmed-meshheading:8143429-Fasting,
pubmed-meshheading:8143429-Food,
pubmed-meshheading:8143429-Homeostasis,
pubmed-meshheading:8143429-Humans,
pubmed-meshheading:8143429-Kinetics,
pubmed-meshheading:8143429-Leucine,
pubmed-meshheading:8143429-Male,
pubmed-meshheading:8143429-Middle Aged,
pubmed-meshheading:8143429-Nitrogen,
pubmed-meshheading:8143429-Oxidation-Reduction
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pubmed:year |
1994
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pubmed:articleTitle |
Nitrogen homoeostasis in man: diurnal changes in nitrogen excretion, leucine oxidation and whole body leucine kinetics during a reduction from a high to a moderate protein intake.
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pubmed:affiliation |
Nutrition Research Unit, London School of Hygiene and Tropical Medicine, St Pancras Hospital, U.K.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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