Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1994-5-5
pubmed:abstractText
Monoclonal antibodies to bovine viral diarrhea virus (BVDV) were examined for binding with a large number of North American BVDV isolates and eight strains of the serologically related pestivirus, hog cholera virus (HCV). No single BVDV monoclonal antibody reacted with all BVDV isolates. The most cross-reactive monoclonal antibody was an anti-p80/p125 antibody which showed a positive reaction with 173 of 180 (96%) North American isolates. From a fewer number of isolates tested, one anti-gp53 monoclonal antibody also showed a high cross-reactivity (94%). All BVDV isolates showed a positive reaction with at least one of the seven monoclonal antibodies in the panel. Thus, the results indicated that a pool of these monoclonal antibodies may be used in place of polyclonal antisera for the detection of BVDV contamination of cell lines or for virus isolation. For HCV, all three anti-p80/p125 monoclonal antibodies reacted positively with all eight virus strains. In contrast, none of the anti-gp53 monoclonal antibodies were reactive to HCV strains. Thus, the anti-gp53 monoclonal antibodies may be useful for distinguishing between usually innocuous BVDV infections and the highly significant HCV infections in swine for foreign animal disease surveillance.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8143258-1335836, http://linkedlifedata.com/resource/pubmed/commentcorrection/8143258-1655059, http://linkedlifedata.com/resource/pubmed/commentcorrection/8143258-1663821, http://linkedlifedata.com/resource/pubmed/commentcorrection/8143258-1696159, http://linkedlifedata.com/resource/pubmed/commentcorrection/8143258-1965635, http://linkedlifedata.com/resource/pubmed/commentcorrection/8143258-2169680, http://linkedlifedata.com/resource/pubmed/commentcorrection/8143258-2447228, http://linkedlifedata.com/resource/pubmed/commentcorrection/8143258-2454527, http://linkedlifedata.com/resource/pubmed/commentcorrection/8143258-2471785, http://linkedlifedata.com/resource/pubmed/commentcorrection/8143258-2541152, http://linkedlifedata.com/resource/pubmed/commentcorrection/8143258-2547817, http://linkedlifedata.com/resource/pubmed/commentcorrection/8143258-2548007, http://linkedlifedata.com/resource/pubmed/commentcorrection/8143258-2549680, http://linkedlifedata.com/resource/pubmed/commentcorrection/8143258-2833200, http://linkedlifedata.com/resource/pubmed/commentcorrection/8143258-2837867, http://linkedlifedata.com/resource/pubmed/commentcorrection/8143258-2986494, http://linkedlifedata.com/resource/pubmed/commentcorrection/8143258-2999027, http://linkedlifedata.com/resource/pubmed/commentcorrection/8143258-3022462, http://linkedlifedata.com/resource/pubmed/commentcorrection/8143258-6087539
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0830-9000
pubmed:author
pubmed:issnType
Print
pubmed:volume
58
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
71-4
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Monoclonal antibodies to bovine viral diarrhea virus: cross-reactivities to field isolates and hog cholera virus strains.
pubmed:affiliation
Agriculture Canada, Animal Diseases Research Institute, Lethbridge, Alberta.
pubmed:publicationType
Journal Article