Linked Life Data

8142559

Source:http://linkedlifedata.com/resource/pubmed/id/8142559

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1994-5-5
pubmed:abstractText
Primordial follicles enter a state of suspended animation when they are formed and constitute a "stockpile" from which all growing follicles are derived. The factors that release individual follicles from their quiescent state are unknown. Many investigators believe that the number of follicles in the primordial stockpile is a major factor in determining the rate at which follicles begin to grow. However, the relationship between the size of the stockpile of primordial follicles and the rate at which follicles move into the growing pool is unclear. The purpose of the present study was to attempt to clarify this relationship. The initial size of the stockpile of primordial follicles was experimentally reduced by exposing rats to various doses of busulphan (BUS) in utero. Ovaries were collected at various ages postpartum and prepared for histological analysis. A computer-controlled image analyzer was used to perform size/frequency analysis of oocytes in control and treated ovaries; onset of follicular growth was recognized by enlargement of the oocyte. There was an inverse correlation between the number of primordial follicles in the ovary at birth and the rate at which they moved into the growing pool. In rats most severely affected by the BUS, all of the remaining follicles began to grow very early in life. By the time these severely affected rats reached adulthood, the stockpile of primordial follicles had been nearly exhausted. Nevertheless, the number of large antral follicles remained at normal levels until the follicular reserve was completely depleted.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0006-3363
pubmed:author
pubmed:issnType
Print
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
421-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Relationship between the supply of primordial follicles and the onset of follicular growth in rats.
pubmed:affiliation
Department of Anatomy, University of Maryland School of Medicine, Baltimore 21201.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.