Linked Life Data

8142142

Source:http://linkedlifedata.com/resource/pubmed/id/8142142

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1994-5-3
pubmed:abstractText
We studied the influence of HIV p24 antigen immune complexing with anti-p24 antibodies on the assessment of their respective levels in HIV-positive sera. ELISAs were used to evaluate anti-p24 antibody levels and p24 antigenemia, with or without acid dissociation. Observations include the following: (1) p24 antigenemia usually coexisted with low anti-p24 levels; (2) the p24 antigen concentration inversely correlated with anti-p24 antibody levels; and (3) acid dissociation increased the percentage of p24 antigen-positive sera, mostly when anti-p24 was low. In contrast, (1) antigenemia and antibodies varied independently in antiretroviral-treated AIDS patients, undetectable p24 antigen coexisting then with low anti-p24; (2) after acid dissociation, antigen was still undetectable in 83% of sera with high antibody levels, and in 20% with low antibody levels; and (3) acid dissociation did not increase low anti-p24 levels. Whereas the first set of observations indicates that p24 antigen and anti-p24 antibodies can be engaged in immune complexes, the second set indicates that p24 antigen and antibodies were not inevitably linked in such complexes: they may actually be indicative of two distinct biological phenomena.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0889-2229
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1251-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Relationship between anti-p24 antibody levels and p24 antigenemia in HIV-infected patients.
pubmed:affiliation
CNRS URA 1463, Paris, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't