| pubmed-article:8139477 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8139477 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8139477 | lifeskim:mentions | umls-concept:C0018557 | lld:lifeskim |
| pubmed-article:8139477 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:8139477 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:8139477 | lifeskim:mentions | umls-concept:C0020473 | lld:lifeskim |
| pubmed-article:8139477 | lifeskim:mentions | umls-concept:C0011847 | lld:lifeskim |
| pubmed-article:8139477 | lifeskim:mentions | umls-concept:C1707455 | lld:lifeskim |
| pubmed-article:8139477 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:8139477 | pubmed:dateCreated | 1994-4-26 | lld:pubmed |
| pubmed-article:8139477 | pubmed:abstractText | Characteristics of the lipoprotein profile and metabolism of triglyceride-rich lipoproteins in diabetic hamsters were investigated to assess their suitability as a model for human diabetic hyperlipidemia. Diabetes was induced in the hamsters by intraperitoneal injection of streptozocin (30 mg/kg) for 3 days and compared with the results in streptozocin-diabetic rats (50 mg/kg intravenously). Similar degrees of hyperglycemia and hypoinsulinemia were observed 8 to 10 days after the final streptozocin injection in both groups. Fasting plasma lipid concentrations were about 2.5 times greater in hamsters than in rats. Plasma cholesterol was principally associated with high-density lipoprotein (HDL) in both rodents, although the distribution in very-low-density lipoprotein (VLDL) and low-density lipoprotein (LDL) was significantly greater in hamsters (44%) than in rats (13%). Diabetes increased the concentrations of triglyceride, cholesterol, and phospholipid 5.6- to 7.8-fold in hamsters, whereas it increased them only 1.3- to 1.6-fold in rats. Diabetic hamsters have a plasma lipoprotein profile similar to that of diabetic man, ie, triglyceride-rich lipoproteins are increased and HDL cholesterol is decreased. The concentration of HDL cholesterol was inversely correlated with the severity of hypertriglyceridemia (r = .76, P < .005). This combination of events does not occur in diabetic rats. Hamsters had a low level of apoprotein B-48-containing triglyceride-rich lipoproteins, although diabetes increased the estimated concentration by fourfold. In rats apoprotein B-48 is the predominant form, but diabetes did not alter the relative proportion of apoprotein B isoforms.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
| pubmed-article:8139477 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8139477 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8139477 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8139477 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8139477 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:8139477 | pubmed:issn | 0026-0495 | lld:pubmed |
| pubmed-article:8139477 | pubmed:author | pubmed-author:TakahashiTT | lld:pubmed |
| pubmed-article:8139477 | pubmed:author | pubmed-author:HiranoTT | lld:pubmed |
| pubmed-article:8139477 | pubmed:author | pubmed-author:NaganoSS | lld:pubmed |
| pubmed-article:8139477 | pubmed:author | pubmed-author:FurukawaSS | lld:pubmed |
| pubmed-article:8139477 | pubmed:author | pubmed-author:EbaraTT | lld:pubmed |
| pubmed-article:8139477 | pubmed:author | pubmed-author:OatsJJ | lld:pubmed |
| pubmed-article:8139477 | pubmed:author | pubmed-author:SakamakiRR | lld:pubmed |
| pubmed-article:8139477 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8139477 | pubmed:volume | 43 | lld:pubmed |
| pubmed-article:8139477 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8139477 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8139477 | pubmed:pagination | 299-305 | lld:pubmed |
| pubmed-article:8139477 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:8139477 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8139477 | pubmed:articleTitle | Hyperlipidemia in streptozocin-diabetic hamsters as a model for human insulin-deficient diabetes: comparison to streptozocin-diabetic rats. | lld:pubmed |
| pubmed-article:8139477 | pubmed:affiliation | Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan. | lld:pubmed |
| pubmed-article:8139477 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8139477 | pubmed:publicationType | Comparative Study | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8139477 | lld:pubmed |
