Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1994-4-26
|
| pubmed:abstractText |
Characteristics of the lipoprotein profile and metabolism of triglyceride-rich lipoproteins in diabetic hamsters were investigated to assess their suitability as a model for human diabetic hyperlipidemia. Diabetes was induced in the hamsters by intraperitoneal injection of streptozocin (30 mg/kg) for 3 days and compared with the results in streptozocin-diabetic rats (50 mg/kg intravenously). Similar degrees of hyperglycemia and hypoinsulinemia were observed 8 to 10 days after the final streptozocin injection in both groups. Fasting plasma lipid concentrations were about 2.5 times greater in hamsters than in rats. Plasma cholesterol was principally associated with high-density lipoprotein (HDL) in both rodents, although the distribution in very-low-density lipoprotein (VLDL) and low-density lipoprotein (LDL) was significantly greater in hamsters (44%) than in rats (13%). Diabetes increased the concentrations of triglyceride, cholesterol, and phospholipid 5.6- to 7.8-fold in hamsters, whereas it increased them only 1.3- to 1.6-fold in rats. Diabetic hamsters have a plasma lipoprotein profile similar to that of diabetic man, ie, triglyceride-rich lipoproteins are increased and HDL cholesterol is decreased. The concentration of HDL cholesterol was inversely correlated with the severity of hypertriglyceridemia (r = .76, P < .005). This combination of events does not occur in diabetic rats. Hamsters had a low level of apoprotein B-48-containing triglyceride-rich lipoproteins, although diabetes increased the estimated concentration by fourfold. In rats apoprotein B-48 is the predominant form, but diabetes did not alter the relative proportion of apoprotein B isoforms.(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins B,
http://linkedlifedata.com/resource/pubmed/chemical/Lipase,
http://linkedlifedata.com/resource/pubmed/chemical/Lipids,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, HDL,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Streptozocin,
http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0026-0495
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
43
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
299-305
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8139477-Animals,
pubmed-meshheading:8139477-Apolipoproteins B,
pubmed-meshheading:8139477-Cricetinae,
pubmed-meshheading:8139477-Diabetes Mellitus, Experimental,
pubmed-meshheading:8139477-Diabetes Mellitus, Type 1,
pubmed-meshheading:8139477-Disease Models, Animal,
pubmed-meshheading:8139477-Hyperlipidemias,
pubmed-meshheading:8139477-Hypertriglyceridemia,
pubmed-meshheading:8139477-Isomerism,
pubmed-meshheading:8139477-Lipase,
pubmed-meshheading:8139477-Lipids,
pubmed-meshheading:8139477-Lipoproteins, HDL,
pubmed-meshheading:8139477-Lipoproteins, LDL,
pubmed-meshheading:8139477-Liver,
pubmed-meshheading:8139477-Male,
pubmed-meshheading:8139477-Mesocricetus,
pubmed-meshheading:8139477-Rats,
pubmed-meshheading:8139477-Rats, Wistar,
pubmed-meshheading:8139477-Streptozocin,
pubmed-meshheading:8139477-Time Factors,
pubmed-meshheading:8139477-Triglycerides
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Hyperlipidemia in streptozocin-diabetic hamsters as a model for human insulin-deficient diabetes: comparison to streptozocin-diabetic rats.
|
| pubmed:affiliation |
Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan.
|
| pubmed:publicationType |
Journal Article,
Comparative Study
|