| pubmed-article:8138158 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8138158 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:8138158 | lifeskim:mentions | umls-concept:C0332597 | lld:lifeskim |
| pubmed-article:8138158 | lifeskim:mentions | umls-concept:C0013139 | lld:lifeskim |
| pubmed-article:8138158 | lifeskim:mentions | umls-concept:C0080141 | lld:lifeskim |
| pubmed-article:8138158 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:8138158 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:8138158 | lifeskim:mentions | umls-concept:C0075804 | lld:lifeskim |
| pubmed-article:8138158 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8138158 | pubmed:dateCreated | 1994-4-25 | lld:pubmed |
| pubmed-article:8138158 | pubmed:abstractText | Segregation Distorter (SD) is a naturally occurring system of meiotic drive in Drosophila melanogaster. Males heterozygous for an SD second chromosome and a normal homolog (SD+) transmit predominantly SD-bearing sperm. To accomplish this, the Segregation distorter (Sd) locus induces the dysfunction of those spermatids that receive the SD+ chromosome. Recently, P. A. Powers and B. Ganetzky isolated overlapping DNA clones spanning the region of DNA known to contain the Sd gene and identified a 5-kb tandem duplication that is present on all SD chromosomes examined, but is apparently absent from wild-type chromosomes. Here we report a molecular analysis of two spontaneous revertants from an Australian SD chromosome (SD-Arm28). Both of these revertants have lost the 5-kb tandem duplication along with the ability to distort transmission; the critical observation, however, is that they retain the DNA haplotype in the flanking regions (both proximally and distally) that is characteristic of the original SD-Arm28. We propose unequal sister chromatid exchange between the tandem repeats as the only plausible explanation for loss of a repeat while retaining flanking markers. This provides direct evidence that the tandem duplication is indeed necessary for the Sd phenotype. Further, we examined testes-specific levels of both RNA and protein for the nearby Topoisomerase 2 gene. Neither revealed a consistent difference between SD and SD+ strains. We also measured testes-specific levels of RNA using the tandem duplication itself as probe. Our results suggest that there is strong up-regulation of one or several 2.0-2.3-kb transcripts from the duplicated region in the testes of an SD strain.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
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| pubmed-article:8138158 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8138158 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8138158 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8138158 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8138158 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8138158 | pubmed:issn | 0016-6731 | lld:pubmed |
| pubmed-article:8138158 | pubmed:author | pubmed-author:WuC ICI | lld:pubmed |
| pubmed-article:8138158 | pubmed:author | pubmed-author:DoshiPP | lld:pubmed |
| pubmed-article:8138158 | pubmed:author | pubmed-author:PalopoliM FMF | lld:pubmed |
| pubmed-article:8138158 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8138158 | pubmed:volume | 136 | lld:pubmed |
| pubmed-article:8138158 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8138158 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8138158 | pubmed:pagination | 209-15 | lld:pubmed |
| pubmed-article:8138158 | pubmed:dateRevised | 2010-9-13 | lld:pubmed |
| pubmed-article:8138158 | pubmed:meshHeading | pubmed-meshheading:8138158-... | lld:pubmed |
| pubmed-article:8138158 | pubmed:meshHeading | pubmed-meshheading:8138158-... | lld:pubmed |
| pubmed-article:8138158 | pubmed:meshHeading | pubmed-meshheading:8138158-... | lld:pubmed |
| pubmed-article:8138158 | pubmed:meshHeading | pubmed-meshheading:8138158-... | lld:pubmed |
| pubmed-article:8138158 | pubmed:meshHeading | pubmed-meshheading:8138158-... | lld:pubmed |
| pubmed-article:8138158 | pubmed:meshHeading | pubmed-meshheading:8138158-... | lld:pubmed |
| pubmed-article:8138158 | pubmed:meshHeading | pubmed-meshheading:8138158-... | lld:pubmed |
| pubmed-article:8138158 | pubmed:meshHeading | pubmed-meshheading:8138158-... | lld:pubmed |
| pubmed-article:8138158 | pubmed:meshHeading | pubmed-meshheading:8138158-... | lld:pubmed |
| pubmed-article:8138158 | pubmed:meshHeading | pubmed-meshheading:8138158-... | lld:pubmed |
| pubmed-article:8138158 | pubmed:meshHeading | pubmed-meshheading:8138158-... | lld:pubmed |
| pubmed-article:8138158 | pubmed:meshHeading | pubmed-meshheading:8138158-... | lld:pubmed |
| pubmed-article:8138158 | pubmed:meshHeading | pubmed-meshheading:8138158-... | lld:pubmed |
| pubmed-article:8138158 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8138158 | pubmed:articleTitle | Characterization of two Segregation distorter revertants: evidence that the tandem duplication is necessary for Sd activity in Drosophila melanogaster. | lld:pubmed |
| pubmed-article:8138158 | pubmed:affiliation | Department of Ecology and Evolution, University of Chicago, Illinois 60637. | lld:pubmed |
| pubmed-article:8138158 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8138158 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8138158 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:35223 | entrezgene:pubmed | pubmed-article:8138158 | lld:entrezgene |
| entrez-gene:35225 | entrezgene:pubmed | pubmed-article:8138158 | lld:entrezgene |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8138158 | lld:pubmed |
