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rdf:type |
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lifeskim:mentions |
umls-concept:C0003241,
umls-concept:C0012634,
umls-concept:C0024141,
umls-concept:C0027697,
umls-concept:C0030705,
umls-concept:C0033684,
umls-concept:C0035544,
umls-concept:C0035668,
umls-concept:C0441655,
umls-concept:C0441889,
umls-concept:C1167298,
umls-concept:C2347930
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pubmed:issue |
3
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pubmed:dateCreated |
1994-4-28
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pubmed:abstractText |
A patient with systemic lupus erythematosus (SLE) and nephritis without antibodies to dsDNA but with antibodies to a 5S RNA/protein (RNP) complex is presented. Combined RNA precipitation and Western blotting experiments strongly suggested that these newly identified autoantibodies recognized a distinct epitope on the L5 ribosomal protein of the L5/5S RNP complex first described by Steitz et al. [1]. Quantification of the anti-5S RNP antibody levels was done by hybridizing Northern blots of immunoprecipitated RNA from serial serum samples with a 32P-labelled oligoprobe specific for the 5S ribosomal RNA. These studies revealed a strong association between anti-5S RNP autoantibody titre and severity of SLE nephritis over a 3-year prospective study. Our results indicate that the L5/5S RNP can be a target of autoimmune response, and and may serve, in some cases, as marker of SLE severity and response to therapy.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8137536-1384511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8137536-1700015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8137536-2203588,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8137536-2346519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8137536-2410526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8137536-2606513,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8137536-2646863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8137536-2684074,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8137536-2760462,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8137536-2968364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8137536-3279045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8137536-3475694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8137536-3501355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8137536-436829,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8137536-6164096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8137536-6164980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8137536-6208365,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8137536-6232278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8137536-6789322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8137536-6806318,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8137536-8508279
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
95
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
385-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8137536-Antibody Specificity,
pubmed-meshheading:8137536-Autoantibodies,
pubmed-meshheading:8137536-Autoimmunity,
pubmed-meshheading:8137536-Humans,
pubmed-meshheading:8137536-Lupus Nephritis,
pubmed-meshheading:8137536-Male,
pubmed-meshheading:8137536-Prospective Studies,
pubmed-meshheading:8137536-RNA, Ribosomal, 5S,
pubmed-meshheading:8137536-Ribonucleoproteins,
pubmed-meshheading:8137536-Ribosomal Proteins,
pubmed-meshheading:8137536-Time Factors
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pubmed:year |
1994
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pubmed:articleTitle |
Anti-5S RNA/protein (RNP) antibody levels correlate with disease activity in a patient with systemic lupus erythematosus (SLE) nephritis.
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pubmed:affiliation |
Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, Athens, Greece.
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pubmed:publicationType |
Journal Article,
Case Reports
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