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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1994-4-25
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pubmed:abstractText |
It has been suggested that normal women receiving oral contraceptives (OC) may develop a series of metabolic side-effects which relate to the risk of cardiovascular disease. These metabolic disturbances include changes in glucose and insulin metabolism, raised serum lipid and lipoprotein concentrations and elevated blood pressure. All these changes indicate that OC might cause insulin resistance. We have prospectively examined the effect of OC on insulin resistance and lipid metabolism including Lp(a) values.
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pubmed:keyword |
http://linkedlifedata.com/resource/pubmed/keyword/Asia,
http://linkedlifedata.com/resource/pubmed/keyword/Biology,
http://linkedlifedata.com/resource/pubmed/keyword/CHINA,
http://linkedlifedata.com/resource/pubmed/keyword/Carbohydrate Metabolic Effects,
http://linkedlifedata.com/resource/pubmed/keyword/Clinical Research,
http://linkedlifedata.com/resource/pubmed/keyword/Contraception,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Methods,
http://linkedlifedata.com/resource/pubmed/keyword/DIET,
http://linkedlifedata.com/resource/pubmed/keyword/Developing Countries,
http://linkedlifedata.com/resource/pubmed/keyword/Eastern Asia,
http://linkedlifedata.com/resource/pubmed/keyword/Family Planning,
http://linkedlifedata.com/resource/pubmed/keyword/Glucose Metabolism Effects,
http://linkedlifedata.com/resource/pubmed/keyword/Health,
http://linkedlifedata.com/resource/pubmed/keyword/LIPIDS,
http://linkedlifedata.com/resource/pubmed/keyword/Lipid Metabolic Effects,
http://linkedlifedata.com/resource/pubmed/keyword/Metabolic Effects,
http://linkedlifedata.com/resource/pubmed/keyword/Nutrition,
http://linkedlifedata.com/resource/pubmed/keyword/Oral Contraceptives,
http://linkedlifedata.com/resource/pubmed/keyword/Oral Contraceptives, Combined,
http://linkedlifedata.com/resource/pubmed/keyword/Oral Contraceptives, Phasic,
http://linkedlifedata.com/resource/pubmed/keyword/Physiology,
http://linkedlifedata.com/resource/pubmed/keyword/Research Report,
http://linkedlifedata.com/resource/pubmed/keyword/Taiwan
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0300-0664
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
249-55
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pubmed:dateRevised |
2011-11-17
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pubmed:otherAbstract |
PIP: In Taipei, Taiwan, physicians started 13 normally menstruating women on an isocaloric diet (30 kcal/kg; 50% carbohydrate, 30% fat, and 20% protein) and administered a combined triphasic oral contraceptive (OC) to evaluate the effect of the OC on insulin resistance and lipid metabolism including Lp(a) values. (Lp(a) levels may be a risk factor for coronary heart disease.) After three months of taking OCs, the plasma glucose concentration increased significantly (p 0.05). The plasma insulin response to oral glucose was also significantly higher than before OC use (p 0.03). The steady state plasma glucose concentration during constant infusion of glucose, insulin, and somatostatin was much higher three months after OC administration than before OC administration (12.4 vs. 7.5 mmol/l; p 0.001). After three cycles of OC use, the only fasting plasma lipoprotein that increased significantly was triglyceride (0.81 vs. 1.09 mmol/l; p 0.03). The Lp (a) levels stayed essentially the same. OC use decreased significantly the concentration of all serum steroids except DHEAS. These findings indicate that administration of a triphasic low dose OC for three cycles caused glucose intolerance, hyperinsulinemia, and insulin resistance in normal women. It also raised plasma triglyceride concentrations, but did not affect Lp(a) and other lipid values.
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pubmed:meshHeading |
pubmed-meshheading:8137525-Adult,
pubmed-meshheading:8137525-Blood Glucose,
pubmed-meshheading:8137525-Contraceptives, Oral, Combined,
pubmed-meshheading:8137525-Female,
pubmed-meshheading:8137525-Glucose Tolerance Test,
pubmed-meshheading:8137525-Humans,
pubmed-meshheading:8137525-Insulin,
pubmed-meshheading:8137525-Insulin Resistance,
pubmed-meshheading:8137525-Lipid Metabolism,
pubmed-meshheading:8137525-Luteal Phase,
pubmed-meshheading:8137525-Prospective Studies,
pubmed-meshheading:8137525-Triglycerides
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pubmed:year |
1994
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pubmed:articleTitle |
Prospective evaluation of insulin resistance and lipid metabolism in women receiving oral contraceptives.
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pubmed:affiliation |
Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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