Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1994-4-25
pubmed:abstractText
This study was prompted by reports of functionally normal humans with micrencephaly or cortical hypoplasia. Methylazoxymethanol acetate (MAM) treatment, which induces micrencephaly in rats, was administered by injection (20 mg/kg) on gestational day 14. Prior to weaning and into adulthood, offspring were assessed on many behavioral tests. There were 3 findings. First, MAM rats (forebrain weight less than 2/3 of controls) were not profoundly hyperactive. Increased activity was seen only on prolonged tests or after amphetamine administration. Second, MAM rats were hypoactive in some conditions. These rats were light shy and less likely to explore lighted areas. MAM rats appeared hyperreactive to environmental stimuli, but not hyperactive. Finally, no MAM effect on behavior was as large as that on brain weight. Thus, as with clinical findings, rat micrencephalics are more remarkable for functional sparing than for behavioral abnormalities.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0735-7044
pubmed:author
pubmed:issnType
Print
pubmed:volume
107
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1067-76
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed-meshheading:8136060-Alkylating Agents, pubmed-meshheading:8136060-Animals, pubmed-meshheading:8136060-Arousal, pubmed-meshheading:8136060-Association Learning, pubmed-meshheading:8136060-Behavior, Animal, pubmed-meshheading:8136060-Brain, pubmed-meshheading:8136060-Cerebral Cortex, pubmed-meshheading:8136060-Conditioning, Classical, pubmed-meshheading:8136060-Discrimination Learning, pubmed-meshheading:8136060-Dose-Response Relationship, Drug, pubmed-meshheading:8136060-Female, pubmed-meshheading:8136060-Male, pubmed-meshheading:8136060-Methamphetamine, pubmed-meshheading:8136060-Methylazoxymethanol Acetate, pubmed-meshheading:8136060-Motor Activity, pubmed-meshheading:8136060-Organ Size, pubmed-meshheading:8136060-Orientation, pubmed-meshheading:8136060-Pregnancy, pubmed-meshheading:8136060-Prenatal Exposure Delayed Effects, pubmed-meshheading:8136060-Problem Solving, pubmed-meshheading:8136060-Rats, pubmed-meshheading:8136060-Rats, Sprague-Dawley
pubmed:year
1993
pubmed:articleTitle
Behavioral effects of methylazoxymethanol-induced micrencephaly.
pubmed:affiliation
Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079.
pubmed:publicationType
Journal Article