| pubmed-article:8135868 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8135868 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8135868 | lifeskim:mentions | umls-concept:C0009368 | lld:lifeskim |
| pubmed-article:8135868 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8135868 | lifeskim:mentions | umls-concept:C1261253 | lld:lifeskim |
| pubmed-article:8135868 | lifeskim:mentions | umls-concept:C1882417 | lld:lifeskim |
| pubmed-article:8135868 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:8135868 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:8135868 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:8135868 | pubmed:dateCreated | 1994-4-20 | lld:pubmed |
| pubmed-article:8135868 | pubmed:abstractText | The metabolism of sulfamethazine (SMZ) and p-aminobenzoic acid (PABA) by N-acetyltransferase (NAT) was measured in human colorectal cytosols from 12 slow and 11 rapid acetylators whose genotype was determined independently by a specific polymerase chain reaction. SMZ metabolism was significantly greater in the rapid than in the slow phenotype (192 +/- 22 versus 94 +/- 11 pmol N-acetylsulfamethazine/min/mg protein), while PABA metabolism was similar in both phenotypes (23.7 +/- 4.4 versus 23.0 +/- 3.9 nmol N-acetyl-p-aminobenzoic acid/min/mg protein). Both monomorphic and polymorphic NAT mRNAs were detected by the polymerase chain reaction in the colorectal mucosa of most samples. The finding that polymorphic NAT is expressed in a phenotype-dependent manner in colorectal mucosa indicates that this tissue has the capacity to participate in local bioactivation of dietary and environmental aryl- or heterocyclic amine carcinogens and may explain, in part, the phenotype-dependent occurrence of colorectal cancer. | lld:pubmed |
| pubmed-article:8135868 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8135868 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8135868 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8135868 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8135868 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8135868 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8135868 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8135868 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8135868 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:8135868 | pubmed:issn | 0006-2952 | lld:pubmed |
| pubmed-article:8135868 | pubmed:author | pubmed-author:IlettK FKF | lld:pubmed |
| pubmed-article:8135868 | pubmed:author | pubmed-author:KadlubarF FFF | lld:pubmed |
| pubmed-article:8135868 | pubmed:author | pubmed-author:LangN PNP | lld:pubmed |
| pubmed-article:8135868 | pubmed:author | pubmed-author:IngramD MDM | lld:pubmed |
| pubmed-article:8135868 | pubmed:author | pubmed-author:MinchinR FRF | lld:pubmed |
| pubmed-article:8135868 | pubmed:author | pubmed-author:TeitelC HCH | lld:pubmed |
| pubmed-article:8135868 | pubmed:author | pubmed-author:CarpenterD... | lld:pubmed |
| pubmed-article:8135868 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8135868 | pubmed:day | 2 | lld:pubmed |
| pubmed-article:8135868 | pubmed:volume | 47 | lld:pubmed |
| pubmed-article:8135868 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8135868 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8135868 | pubmed:pagination | 914-7 | lld:pubmed |
| pubmed-article:8135868 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:8135868 | pubmed:meshHeading | pubmed-meshheading:8135868-... | lld:pubmed |
| pubmed-article:8135868 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8135868 | pubmed:articleTitle | Expression of monomorphic and polymorphic N-acetyltransferases in human colon. | lld:pubmed |
| pubmed-article:8135868 | pubmed:affiliation | Department of Pharmacology, University of Western Australia, Nedlands. | lld:pubmed |
| pubmed-article:8135868 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8135868 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:8135868 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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