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rdf:type |
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lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0017262,
umls-concept:C0017337,
umls-concept:C0023206,
umls-concept:C0027882,
umls-concept:C0040132,
umls-concept:C0040160,
umls-concept:C0040845,
umls-concept:C0185117,
umls-concept:C0205263,
umls-concept:C1510411,
umls-concept:C1749467,
umls-concept:C2911684
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pubmed:issue |
2
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pubmed:dateCreated |
1994-4-21
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pubmed:abstractText |
Expression of the soluble lectin L-14 is low in normal and very high in transformed thyroid cells. We show that L-14 gene expression is transiently induced upon thyrotropin stimulation of normal quiescent FRTL-5 rat thyroid cells. Permanent activation of L-14 gene expression is obtained in the same cells infected with a wild-type and a temperature sensitive mutant of Kirsten murine sarcoma virus, both at the permissive and non permissive temperature for transformation. We also find that L-14 mRNA is undetectable in rat brain but is abundant in rat oligodendrocytes precursors transformed by polyoma middle T oncogene. Retinoic acid treatment of these transformed cells leads to acquisition of a differentiated phenotype accompanied by a 30-fold decrease of L-14 mRNA levels. Removal of retinoic acid restores both the transformed undifferentiated phenotype and high L-14 expression. Taken together these results indicate that growth stimulation and induction of cell differentiation are accompanied by strong modulation of L-14 gene expression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
199
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
540-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8135794-Animals,
pubmed-meshheading:8135794-Base Sequence,
pubmed-meshheading:8135794-Carrier Proteins,
pubmed-meshheading:8135794-Cell Division,
pubmed-meshheading:8135794-Cell Line,
pubmed-meshheading:8135794-Cell Transformation, Neoplastic,
pubmed-meshheading:8135794-DNA,
pubmed-meshheading:8135794-Fibroblasts,
pubmed-meshheading:8135794-Galectins,
pubmed-meshheading:8135794-Gene Expression,
pubmed-meshheading:8135794-Hemagglutinins,
pubmed-meshheading:8135794-Kinetics,
pubmed-meshheading:8135794-Kirsten murine sarcoma virus,
pubmed-meshheading:8135794-Molecular Sequence Data,
pubmed-meshheading:8135794-Oligodendroglia,
pubmed-meshheading:8135794-Oligonucleotide Probes,
pubmed-meshheading:8135794-RNA, Messenger,
pubmed-meshheading:8135794-Rats,
pubmed-meshheading:8135794-Thymidine,
pubmed-meshheading:8135794-Thyroid Gland,
pubmed-meshheading:8135794-Thyrotropin,
pubmed-meshheading:8135794-Tretinoin
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pubmed:year |
1994
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pubmed:articleTitle |
Expression of the soluble lectin L-14 gene is induced by TSH in thyroid cells and suppressed by retinoic acid in transformed neural cells.
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pubmed:affiliation |
Dipartimento di Biologia e Patologia Cellulare e Molecolare L. Califano, Università degli Studi di Napoli, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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