Linked Life Data

8134540

Source:http://linkedlifedata.com/resource/pubmed/id/8134540

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1994-4-18
pubmed:abstractText
Dose-response relationships for X-ray-induced reciprocal translocations in spermatogonial stem cells of mutant and wild-type mice were established by spermatocyte analysis many cell generations after irradiation. The mutants studied were Wv/+, the viable allele of dominant spotting in the heterozygous state, and Slcon/Slcon, the homozygous contrasted allele of steel. The results show that the recovered yield of translocations was lowered in both mutants with steel being most extreme. Remarkably, however, no indications for enhanced cell killing were obtained in the mutants, and consequently the peak yields of translocations occurred at about the same dose level (6 Gy) as in normal mice. Histological analysis suggested that the postirradiation recovery of the germinal epithelium was retarded in the mutants with the effect in the steel mice again being most extreme. These differences in differentiation-multiplication patterns of regenerating spermatogonia after irradiation are probably responsible for the reduced recovery of translocations from the mutant mice.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0033-7587
pubmed:author
pubmed:issnType
Print
pubmed:volume
137
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
171-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Reduced recovery of translocations from X-irradiated spermatogonial stem cells of dominant spotting (Wv/+) and steel (Slcon/Slcon) mice.
pubmed:affiliation
MGC-Department of Radiation Genetics and Chemical Mutagenesis, State University of Leiden, Sylvius Laboratory, The Netherlands.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't