| pubmed-article:8133891 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8133891 | lifeskim:mentions | umls-concept:C0085112 | lld:lifeskim |
| pubmed-article:8133891 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:8133891 | lifeskim:mentions | umls-concept:C0376515 | lld:lifeskim |
| pubmed-article:8133891 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8133891 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:8133891 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:8133891 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:8133891 | pubmed:issue | 6470 | lld:pubmed |
| pubmed-article:8133891 | pubmed:dateCreated | 1994-4-19 | lld:pubmed |
| pubmed-article:8133891 | pubmed:abstractText | Expression of antigen receptors is vital for the development of B and T lymphocytes. In mice with the scid mutation, which are unable to make productive rearrangements of their immunoglobulin and T-cell receptor (TCR) genes, lymphopoiesis aborts at an early stage. The death of the immature lymphocytes by apoptosis is postulated to result from a failure to receive a survival signal induced by receptor engagement. Consistent with this hypothesis, introduction of immunoglobulin or TCR transgenes into scid mice promoted an increase in B- or T-lymphoid cells, respectively. As the protein encoded by the bcl-2 gene can inhibit cell death, we tested whether lymphopoiesis could be rescued in scid mice by crossing in a bcl-2 transgene. Strikingly, the bcl-2/scid mice accumulated almost normal numbers of B-lymphoid cells which lacked surface immunoglobulin but expressed markers of maturity. T-cell development remained blocked. Introducing a TCR transgene enabled bcl-2/scid mice to develop normal numbers of CD4+8+ thymocytes even in the absence of immunological selection, suggesting that T cells become competent to respond to bcl-2 protein only after the TCR complex is displayed at the cell surface. | lld:pubmed |
| pubmed-article:8133891 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8133891 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8133891 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8133891 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8133891 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:8133891 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:8133891 | pubmed:author | pubmed-author:CorySS | lld:pubmed |
| pubmed-article:8133891 | pubmed:author | pubmed-author:HarrisA WAW | lld:pubmed |
| pubmed-article:8133891 | pubmed:author | pubmed-author:StrasserAA | lld:pubmed |
| pubmed-article:8133891 | pubmed:author | pubmed-author:CorcoranL MLM | lld:pubmed |
| pubmed-article:8133891 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8133891 | pubmed:day | 31 | lld:pubmed |
| pubmed-article:8133891 | pubmed:volume | 368 | lld:pubmed |
| pubmed-article:8133891 | pubmed:geneSymbol | bcl-2 | lld:pubmed |
| pubmed-article:8133891 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8133891 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8133891 | pubmed:pagination | 457-60 | lld:pubmed |
| pubmed-article:8133891 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:8133891 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8133891 | pubmed:articleTitle | Bcl-2 expression promotes B- but not T-lymphoid development in scid mice. | lld:pubmed |
| pubmed-article:8133891 | pubmed:affiliation | Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia. | lld:pubmed |
| pubmed-article:8133891 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8133891 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8133891 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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