Linked Life Data

8133835

Source:http://linkedlifedata.com/resource/pubmed/id/8133835

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1994-4-18
pubmed:abstractText
Allergic diseases are among the most common diseases in childhood and their prevalence is 14%. One of the most important pathogenetic factors is the ability to produce IgE and the measurement of cord serum IgE seems to be very important for early detection of newborns at risk. Besides, cigarette smoke, among the environmental factors, has been demonstrated to influence the immunologic system, inducing an increase in IgE production. The aim of this study is to evaluate fetal production of IgE in newborns with a family history of atopy and whose mother has been smoking during pregnancy. The measurement of cord serum IgE has been performed in 215 at term newborns (weight at birth > 2500 g, Apgar score at 5' > 7). A careful history has been obtained with particular regard at the presence of familiarity for allergies and a cigarette smoking during pregnancy. According to the history, children have been divided in 3 groups: Group 1: 126 newborns without familiar history of allergy and born from no smoking mothers (control group); Group 2: 46 newborns with familiar history for allergy and born from no smoking mothers; Group 3: 43 newborns without familiar history for allergy born from smoking mothers. The II and III groups of newborns present total IgE levels on cord serum significantly higher than the control group. Besides a positive correlation between the number of cigarettes smoked during pregnancy and the value of cord serum IgE has been detected. It is well known that both genetic and environmental factors play an important role in the pathogenesis of allergic diseases.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
ita
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0026-4946
pubmed:author
pubmed:issnType
Print
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
443-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
[Influence of maternal smoking on cord serum IgE levels in newborns].
pubmed:affiliation
Clinica Pediatrica III, Università degli Studi di Milano.
pubmed:publicationType
Journal Article, Comparative Study, English Abstract