| pubmed-article:8132354 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8132354 | lifeskim:mentions | umls-concept:C1622980 | lld:lifeskim |
| pubmed-article:8132354 | lifeskim:mentions | umls-concept:C0022984 | lld:lifeskim |
| pubmed-article:8132354 | lifeskim:mentions | umls-concept:C0025248 | lld:lifeskim |
| pubmed-article:8132354 | lifeskim:mentions | umls-concept:C0699748 | lld:lifeskim |
| pubmed-article:8132354 | lifeskim:mentions | umls-concept:C0521033 | lld:lifeskim |
| pubmed-article:8132354 | lifeskim:mentions | umls-concept:C1167622 | lld:lifeskim |
| pubmed-article:8132354 | lifeskim:mentions | umls-concept:C0181586 | lld:lifeskim |
| pubmed-article:8132354 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:8132354 | lifeskim:mentions | umls-concept:C1627358 | lld:lifeskim |
| pubmed-article:8132354 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:8132354 | pubmed:dateCreated | 1994-4-21 | lld:pubmed |
| pubmed-article:8132354 | pubmed:abstractText | Extracellular matrix protein laminin binds specifically to yeast forms of Paracoccidioides brasiliensis and enhances adhesion of the fungus to the surface of epithelial Madin-Darby canine kidney cells in vitro. Immunoblotting of fungal extracts showed that the gp43 glycoprotein is responsible for adhesion. This was confirmed by binding assays using purified gp43, with a Kd of 3.7 nM. The coating of P. brasiliensis yeast forms with laminin before injection into hamster testicles enhanced the fungus virulence, resulting in a faster and more severe granulomatous disease. These results indicate that interaction of fungi with extracellular matrix elements may constitute a basis for the evolution of fungal infection toward regional spreading and dissemination. | lld:pubmed |
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| pubmed-article:8132354 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8132354 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8132354 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8132354 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8132354 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:8132354 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:8132354 | pubmed:author | pubmed-author:de SouzaWW | lld:pubmed |
| pubmed-article:8132354 | pubmed:author | pubmed-author:LopesJ DJD | lld:pubmed |
| pubmed-article:8132354 | pubmed:author | pubmed-author:TravassosL... | lld:pubmed |
| pubmed-article:8132354 | pubmed:author | pubmed-author:FrancoM FMF | lld:pubmed |
| pubmed-article:8132354 | pubmed:author | pubmed-author:de MoraesJ... | lld:pubmed |
| pubmed-article:8132354 | pubmed:author | pubmed-author:VicentiniA... | lld:pubmed |
| pubmed-article:8132354 | pubmed:author | pubmed-author:GesztesiJ LJL | lld:pubmed |
| pubmed-article:8132354 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8132354 | pubmed:volume | 62 | lld:pubmed |
| pubmed-article:8132354 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8132354 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8132354 | pubmed:pagination | 1465-9 | lld:pubmed |
| pubmed-article:8132354 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8132354 | pubmed:meshHeading | pubmed-meshheading:8132354-... | lld:pubmed |
| pubmed-article:8132354 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8132354 | pubmed:articleTitle | Binding of Paracoccidioides brasiliensis to laminin through surface glycoprotein gp43 leads to enhancement of fungal pathogenesis. | lld:pubmed |
| pubmed-article:8132354 | pubmed:affiliation | Disciplina de Biologia Celular, Escola Paulista de Medicina, São Paulo, Brazil. | lld:pubmed |
| pubmed-article:8132354 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8132354 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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