| pubmed-article:8131203 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8131203 | lifeskim:mentions | umls-concept:C0007452 | lld:lifeskim |
| pubmed-article:8131203 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:8131203 | lifeskim:mentions | umls-concept:C0020856 | lld:lifeskim |
| pubmed-article:8131203 | lifeskim:mentions | umls-concept:C0026249 | lld:lifeskim |
| pubmed-article:8131203 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:8131203 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8131203 | pubmed:dateCreated | 1994-4-19 | lld:pubmed |
| pubmed-article:8131203 | pubmed:abstractText | The effect of interferon-gamma (IFN-gamma) antibody production by anti-mu- or pokeweed mitogen-stimulated bovine B cells was studied. IFN-gamma induced IgG2 secretion in isolated bulk B cell populations and in B cells sorted for IgM expression. IgM production was suppressed by the presence of IFN-gamma alone but this effect was antagonized by interleukin 2 (IL2). The effects of IFN-gamma on secreted levels of IgM, IgG1, and IgG2 correlated with the frequencies of cells expressing transcripts of the respective isotypes when stimulated with IFN-gamma-containing T cell supernatants. These results indicate that IFN-gamma plays a key role in IgG2 production in the bovine by directly affecting suitably stimulated B cells. The ability of IL2 to synergize with IFN-gamma to augment both the IgM and IgG2 responses implicates a TH1-like subset in regulation of this isotype. | lld:pubmed |
| pubmed-article:8131203 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8131203 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8131203 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8131203 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8131203 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:8131203 | pubmed:issn | 0008-8749 | lld:pubmed |
| pubmed-article:8131203 | pubmed:author | pubmed-author:AllenG KGK | lld:pubmed |
| pubmed-article:8131203 | pubmed:author | pubmed-author:EstesD MDM | lld:pubmed |
| pubmed-article:8131203 | pubmed:author | pubmed-author:ClosserN MNM | lld:pubmed |
| pubmed-article:8131203 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8131203 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8131203 | pubmed:volume | 154 | lld:pubmed |
| pubmed-article:8131203 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8131203 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8131203 | pubmed:pagination | 287-95 | lld:pubmed |
| pubmed-article:8131203 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:8131203 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8131203 | pubmed:articleTitle | IFN-gamma stimulates IgG2 production from bovine B cells costimulated with anti-mu and mitogen. | lld:pubmed |
| pubmed-article:8131203 | pubmed:affiliation | University of Missouri, College of Veterinary Medicine, Department of Veterinary Microbiology, Columbia 65211. | lld:pubmed |
| pubmed-article:8131203 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8131203 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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