Linked Life Data

8131203

Source:http://linkedlifedata.com/resource/pubmed/id/8131203

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1994-4-19
pubmed:abstractText
The effect of interferon-gamma (IFN-gamma) antibody production by anti-mu- or pokeweed mitogen-stimulated bovine B cells was studied. IFN-gamma induced IgG2 secretion in isolated bulk B cell populations and in B cells sorted for IgM expression. IgM production was suppressed by the presence of IFN-gamma alone but this effect was antagonized by interleukin 2 (IL2). The effects of IFN-gamma on secreted levels of IgM, IgG1, and IgG2 correlated with the frequencies of cells expressing transcripts of the respective isotypes when stimulated with IFN-gamma-containing T cell supernatants. These results indicate that IFN-gamma plays a key role in IgG2 production in the bovine by directly affecting suitably stimulated B cells. The ability of IL2 to synergize with IFN-gamma to augment both the IgM and IgG2 responses implicates a TH1-like subset in regulation of this isotype.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0008-8749
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
154
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
287-95
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
IFN-gamma stimulates IgG2 production from bovine B cells costimulated with anti-mu and mitogen.
pubmed:affiliation
University of Missouri, College of Veterinary Medicine, Department of Veterinary Microbiology, Columbia 65211.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't