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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1994-4-21
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pubmed:abstractText |
The diffusion of valproate (VPA) and trans-2-en-valproate were studied in agar gel and in the cerebral cortex of the rat using pressure microejection and VPA-selective microelectrodes. From the agar measurements a free diffusion coefficient for VPA of 6.52 x 10(-6) cm2.s-1 and for trans-2-en-VPA of 5.25 x 10(-6) cm2.s-1 for 37 degrees C was determined. The tortuosity value in the cortex was 1.92 for VPA and 1.67 for trans-2-en-VPA. The tortuosity values suggest that VPA and trans-2-en-VPA diffuse mainly in the extracellular space of the brain.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0006-8993
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
24
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pubmed:volume |
631
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
187-90
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:8131047-Agar,
pubmed-meshheading:8131047-Animals,
pubmed-meshheading:8131047-Cerebral Cortex,
pubmed-meshheading:8131047-Diffusion,
pubmed-meshheading:8131047-Extracellular Space,
pubmed-meshheading:8131047-Fatty Acids, Monounsaturated,
pubmed-meshheading:8131047-Male,
pubmed-meshheading:8131047-Microelectrodes,
pubmed-meshheading:8131047-Microinjections,
pubmed-meshheading:8131047-Quaternary Ammonium Compounds,
pubmed-meshheading:8131047-Rats,
pubmed-meshheading:8131047-Rats, Sprague-Dawley,
pubmed-meshheading:8131047-Valproic Acid
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pubmed:year |
1993
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pubmed:articleTitle |
Diffusion analysis of valproate and trans-2-en-valproate in agar and in cerebral cortex of the rat.
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pubmed:affiliation |
Institut für Physiologie der Universität Münster, FRG.
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pubmed:publicationType |
Journal Article
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