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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1994-4-15
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pubmed:abstractText |
Correlational and discriminant analyses were applied to "resting" state (eyes covered, ears plugged) regional cerebral glucose metabolic data, obtained with positron emission tomography (PET) and [18F] fluorodeoxyglucose in 14 retarded adults with Down syndrome (10 men, 4 women; age 26-38 years) and 17 age- and sex-matched controls. Down and control subjects showed no differences in the pattern of correlations. However, a discriminant function, reflecting regional interactions involving primary language areas, successfully classified the Down (100%) and control (88%) subjects. The results are consistent with a disruption of brain regional interactions involving language areas in adults with Down syndrome.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0093-934X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
46
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1-20
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8131038-Adult,
pubmed-meshheading:8131038-Brain,
pubmed-meshheading:8131038-Cerebral Cortex,
pubmed-meshheading:8131038-Down Syndrome,
pubmed-meshheading:8131038-Female,
pubmed-meshheading:8131038-Functional Laterality,
pubmed-meshheading:8131038-Glucose,
pubmed-meshheading:8131038-Humans,
pubmed-meshheading:8131038-Intelligence Tests,
pubmed-meshheading:8131038-Language Development Disorders,
pubmed-meshheading:8131038-Language Tests,
pubmed-meshheading:8131038-Male,
pubmed-meshheading:8131038-Neuropsychological Tests,
pubmed-meshheading:8131038-Regression Analysis,
pubmed-meshheading:8131038-Tomography, Emission-Computed
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pubmed:year |
1994
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pubmed:articleTitle |
Abnormal pattern of cerebral glucose metabolic rates involving language areas in young adults with Down syndrome.
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pubmed:affiliation |
Laboratory of Neurosciences, National Institute on Aging, Bethesda, Maryland 20892.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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