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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5152
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pubmed:dateCreated |
1994-4-13
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pubmed:abstractText |
The gamma chain of the interleukin-2 (IL-2) receptor is shared with the functional IL-4 receptor and is causatively related to X-linked severe combined immunodeficiency (XSCID), which is ascribed to a profound T cell defect. Studies with monoclonal antibodies specific for the IL-2 receptor gamma chain showed that the gamma chain participates in the functional high-affinity receptor complexes for IL-7 that are involved in the differentiation of T and B cells. Participation of the gamma subunit in more than one receptor may enable the elucidation of the mechanisms of XSCID development and lymphocyte differentiation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
11
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pubmed:volume |
263
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1453-4
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:8128231-Animals,
pubmed-meshheading:8128231-Antibodies, Monoclonal,
pubmed-meshheading:8128231-B-Lymphocytes,
pubmed-meshheading:8128231-Cell Line,
pubmed-meshheading:8128231-Cells, Cultured,
pubmed-meshheading:8128231-Female,
pubmed-meshheading:8128231-Genetic Linkage,
pubmed-meshheading:8128231-Interleukin-7,
pubmed-meshheading:8128231-Mice,
pubmed-meshheading:8128231-Mice, Inbred C57BL,
pubmed-meshheading:8128231-Receptors, Interleukin,
pubmed-meshheading:8128231-Receptors, Interleukin-2,
pubmed-meshheading:8128231-Receptors, Interleukin-7,
pubmed-meshheading:8128231-Severe Combined Immunodeficiency,
pubmed-meshheading:8128231-T-Lymphocytes,
pubmed-meshheading:8128231-X Chromosome
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pubmed:year |
1994
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pubmed:articleTitle |
Functional participation of the IL-2 receptor gamma chain in IL-7 receptor complexes.
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pubmed:affiliation |
Department of Microbiology, Tohoku University School of Medicine, Sendai, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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