Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6469
pubmed:dateCreated
1994-4-11
pubmed:abstractText
Catechol O-methyltransferase (COMT, EC 2.1.1.6) is important in the central nervous system because it metabolizes catecholamine neurotransmitters such as dopamine. The enzyme catalyses the transfer of the methyl group from S-adenosyl-L-methionine (AdoMet) to one hydroxyl group of catechols. COMT also inactivates catechol-type compounds such as L-DOPA. With selective inhibitors of COMT in combination with L-DOPA, a new principle has been realized in the therapy of Parkinson's disease. Here we solve the atomic structure of COMT to 2.0 A resolution, which provides new insights into the mechanism of the methyl transfer reaction. The co-enzyme-binding domain is strikingly similar to that of an AdoMet-dependent DNA methylase, indicating that all AdoMet methylases may have a common structure.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0028-0836
pubmed:author
pubmed:issnType
Print
pubmed:day
24
pubmed:volume
368
pubmed:geneSymbol
COMT
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
354-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:8127373-Adenosine, pubmed-meshheading:8127373-Amino Acid Sequence, pubmed-meshheading:8127373-Animals, pubmed-meshheading:8127373-Binding Sites, pubmed-meshheading:8127373-Catechol O-Methyltransferase, pubmed-meshheading:8127373-Catecholamines, pubmed-meshheading:8127373-Coenzymes, pubmed-meshheading:8127373-Consensus Sequence, pubmed-meshheading:8127373-Crystallography, X-Ray, pubmed-meshheading:8127373-DNA Modification Methylases, pubmed-meshheading:8127373-Escherichia coli, pubmed-meshheading:8127373-Humans, pubmed-meshheading:8127373-Liver, pubmed-meshheading:8127373-Methionine, pubmed-meshheading:8127373-Methylation, pubmed-meshheading:8127373-Models, Molecular, pubmed-meshheading:8127373-Rats, pubmed-meshheading:8127373-Recombinant Proteins, pubmed-meshheading:8127373-Sequence Homology, Amino Acid
pubmed:year
1994
pubmed:articleTitle
Crystal structure of catechol O-methyltransferase.
pubmed:affiliation
Orion Corporation, Espoo, Finland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't