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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1994-4-12
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pubmed:abstractText |
Malignant histiocytosis (MH) is a rare, rapidly fatal disorder, characterized by systemic proliferation of abnormal histiocytes. Most patients present with pancytopenia. We report the case of a patient with MH in the leukaemic stage, who presented extremely pronounced general symptoms and multisystemic involvement. Determination of serum cytokines showed high levels of tumor necrosis factor (TNF), interleukin 6 (IL-6) and interleukin 1 receptor antagonist (IL-1ra). Cytogenetic studies proved the monoclonality of the histiocytic proliferation. These findings strongly suggest that we are dealing with a proliferation of activated macrophages (= histiocytes). By analogy with the monoblastic (M5a) and monocytic (M5b) acute leukaemia of the French-American-British (FAB) classification, we propose a new entity, 'M5c', designating acute histiocytic leukaemia.
|
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0887-6924
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
502-6
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:8127155-Bone Marrow,
pubmed-meshheading:8127155-Cytokines,
pubmed-meshheading:8127155-Fatal Outcome,
pubmed-meshheading:8127155-Histiocytic Sarcoma,
pubmed-meshheading:8127155-Humans,
pubmed-meshheading:8127155-Hyperplasia,
pubmed-meshheading:8127155-Leukemia, Monocytic, Acute,
pubmed-meshheading:8127155-Macrophage Activation,
pubmed-meshheading:8127155-Male,
pubmed-meshheading:8127155-Middle Aged
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pubmed:year |
1994
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pubmed:articleTitle |
Malignant histiocytosis in the leukaemic stage: a new entity (M5c-AML) in the FAB classification?
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pubmed:affiliation |
Division of Hematology, Hôpital Cantonal Universitaire, Geneva, Switzerland.
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pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
|