Linked Life Data

8126799

Source:http://linkedlifedata.com/resource/pubmed/id/8126799

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1994-4-8
pubmed:abstractText
Patients with suprasacral spinal cord injury usually exhibit severe lower urinary tract dysfunction, which is generally attributed to loss of supraspinal input to the spinal micturition centers. However, some of the dysfunction may also arise secondary to bladder overdistension during the initial period of bladder areflexia. This study evaluated the consequences of bladder overdistension by performing urinary diversion in spinalized (T8-T10) rats. Bladder function was evaluated in urethane-anesthetized control and spinalized animals approximately 24 days after diversion. Chronically spinalized diverted and nondiverted rats exhibited similar micturition dysfunction: bladder/sphincter dyssynergia, incomplete voiding and ineffective (nonvoiding) bladder contractions. These data indicate that neither the condition of the bladder (such as chronic overdistension or bladder hypertrophy) nor afferent input from the bladder to the spinal cord dictates the development of reflex micturition and micturition dysfunction after spinal cord injury, suggesting that the dysfunction is intrinsic to spinal micturition reflex pathways.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0022-5347
pubmed:author
pubmed:issnType
Print
pubmed:volume
151
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1088-91
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Effect of urinary diversion on the recovery of micturition reflexes after spinal cord injury in the rat.
pubmed:affiliation
Department of Pharmacology, University of Pittsburgh, Pennsylvania 15261.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't