Linked Life Data

8126458

Source:http://linkedlifedata.com/resource/pubmed/id/8126458

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1994-4-11
pubmed:abstractText
The role of brain neurotransmitter transport processes in rabies virus infection of neurons was examined. The uptake and release of gamma-amino-n-butyric acid (GABA) in rabies virus-infected embryonic rat cortical neurons was assayed using tritiated ligands. A 45% reduction of [3H]GABA uptake was observed 3 days post-infection, when a maximum level of infectious particle release occurs. At this time, kinetic analysis revealed significant changes in Vmax, whereas no changes were found in Km values in comparison with the control values. K+ and veratridine-induced [3H]GABA release was increased in infected cultures (98% and 35%, respectively) as compared with control values. The results obtained from rabies virus-infected cultures provide some preliminary evidence of the involvement of GABA in the pathogenesis of rabies.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0022-1317
pubmed:author
pubmed:issnType
Print
pubmed:volume
75 ( Pt 3)
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
623-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Modification of tritiated gamma-amino-n-butyric acid transport in rabies virus-infected primary cortical cultures.
pubmed:affiliation
Rabies Unit, Pasteur Institute, Paris, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't