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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1994-4-14
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pubmed:abstractText |
Infection with Helicobacter pylori has been associated with the pathogenesis of chronic active gastritis and gastric and duodenal ulcer disease. Detection of immunoglobulin G antibodies to H. pylori offers a simple alternative to direct detection of the organism in biopsied tissue by culture or histopathological methods. A rapid flow-through membrane-based enzyme immunoassay for the detection of human immunoglobulin G antibodies to H. pylori has been developed and evaluated. Clinical evaluations were performed with 256 patient serum samples obtained from four clinical sites. Biopsy samples were obtained by endoscopic procedures at the same time as the serum samples, and were histopathologically and microbiologically categorized for the presence or absence of H. pylori. Sensitivity and specificity for this rapid enzyme immunoassay were 92 and 88%, respectively, compared directly with endoscopy results. After discordant results were resolved by a quantitative microwell enzyme-linked immunosorbent assay, the resulting sensitivity and specificity were 94 and > 99%, respectively. These results indicate that this rapid enzyme immunoassay is a useful technique to determine H. pylori infection status and is a viable alternative to invasive endoscopic procedures.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8126203-1348298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8126203-1452698,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8126203-1488662,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8126203-1571505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8126203-1624571,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8126203-1732120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8126203-1993767,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8126203-2300088,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8126203-2549098,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8126203-2586553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8126203-3288028,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8126203-3463897,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8126203-3693542,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8126203-3735391,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8126203-3805774,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8126203-3982346,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8126203-8354918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8126203-8436350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8126203-8449560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8126203-8485267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8126203-8511512
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0095-1137
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
46-50
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8126203-Adult,
pubmed-meshheading:8126203-Aged,
pubmed-meshheading:8126203-Aged, 80 and over,
pubmed-meshheading:8126203-Antibodies, Bacterial,
pubmed-meshheading:8126203-Duodenal Ulcer,
pubmed-meshheading:8126203-Evaluation Studies as Topic,
pubmed-meshheading:8126203-Female,
pubmed-meshheading:8126203-Gastritis,
pubmed-meshheading:8126203-Helicobacter Infections,
pubmed-meshheading:8126203-Helicobacter pylori,
pubmed-meshheading:8126203-Humans,
pubmed-meshheading:8126203-Immunoenzyme Techniques,
pubmed-meshheading:8126203-Immunoglobulin G,
pubmed-meshheading:8126203-Male,
pubmed-meshheading:8126203-Middle Aged,
pubmed-meshheading:8126203-Stomach Ulcer
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pubmed:year |
1994
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pubmed:articleTitle |
Evaluation of a new immunodiagnostic assay for Helicobacter pylori antibody detection: correlation with histopathological and microbiological results.
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pubmed:affiliation |
Quidel Corporation, San Diego, California 92121.
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pubmed:publicationType |
Journal Article,
Comparative Study
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