Linked Life Data

8125955

Source:http://linkedlifedata.com/resource/pubmed/id/8125955

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1994-4-12
pubmed:abstractText
NF1 is a family of polypeptides that binds to discrete DNA motifs and plays varying roles in the regulation of gene expression. These polypeptides are also thought to mediate the expression of differentiation-specific markers such as adipocyte and mammary cell type-specific genes. The expression of a number of cellular differentiation-specific markers is down-regulated during neoplastic transformation. We therefore investigated whether oncogenic transformation interferes with the action of NF1. Stable transfection of activated Ha-ras into a number of murine cells correlated with a down-regulation of the expression of the NF1 genes NF1/CTF and NF1/X. The down-regulation was not at the transcriptional level but at the level of stability of the NF1 mRNAs. The level of the DNA binding activity of the NF1 proteins was also reduced in Ha-v-ras-transformed cells, and the expression of a gene that depends on this family of transcription factors was specifically repressed. These results demonstrate that an activated Ha-ras-induced pathway destabilizes the half-life of mRNAs encoding specific members in the NF1 family of transcription factors, which leads to a decrease in NF1-dependent gene expression.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0021-9258
pubmed:author
pubmed:issnType
Print
pubmed:day
11
pubmed:volume
269
pubmed:geneSymbol
Ha-v-ras, NF1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7371-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:8125955-Animals, pubmed-meshheading:8125955-Base Sequence, pubmed-meshheading:8125955-Cell Transformation, Neoplastic, pubmed-meshheading:8125955-Cells, Cultured, pubmed-meshheading:8125955-DNA-Binding Proteins, pubmed-meshheading:8125955-Down-Regulation, pubmed-meshheading:8125955-Gene Expression Regulation, pubmed-meshheading:8125955-Genes, ras, pubmed-meshheading:8125955-Half-Life, pubmed-meshheading:8125955-Mammary Glands, Animal, pubmed-meshheading:8125955-Mice, pubmed-meshheading:8125955-Molecular Sequence Data, pubmed-meshheading:8125955-NFI Transcription Factors, pubmed-meshheading:8125955-Oligodeoxyribonucleotides, pubmed-meshheading:8125955-RNA, Messenger, pubmed-meshheading:8125955-RNA Processing, Post-Transcriptional, pubmed-meshheading:8125955-Transcription Factors
pubmed:year
1994
pubmed:articleTitle
Post-transcriptional down-regulation of expression of transcription factor NF1 by Ha-ras oncogene.
pubmed:affiliation
Kernforschungszentrum Karlsruhe, Institut für Genetik, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't