Linked Life Data

8125749

Source:http://linkedlifedata.com/resource/pubmed/id/8125749

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1994-4-12
pubmed:abstractText
The primary stroma of the developing avian cornea is a highly organized extracellular matrix composed largely of striated collagen fibrils synthesized by the epithelium. These fibrils are heterotypic structures consisting of at least two different fibrillar collagen types (I and II) and probably a fibril-associated collagen (type IX). The epithelial derivation and vectorial secretion of the components of this matrix provide an advantageous system to study the steps in the assembly of this developmentally regulated matrix, as well as in the assembly and maturation of heterotypic collagen fibrils in general. To ascertain when and where two of the collagens of the primary stroma (collagen types II and IX) are assembled into fibrils, monoclonal antibodies were used that bind to the newly deposited, "immature" (non-cross-linked) forms of these molecules, but not to ones that have been assembled into fibrils and have become cross-linked.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0146-0404
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
862-9
pubmed:dateRevised
2010-3-24
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Collagen fibril assembly in the developing avian primary corneal stroma.
pubmed:affiliation
Department of Anatomy and Cellular Biology, Tufts University Medical School, Boston, Massachusetts 02111.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.