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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
|
| pubmed:dateCreated |
1994-4-11
|
| pubmed:abstractText |
Arachidonic acid is released from membrane phospholipids in a receptor-dependent manner when neurons or glial cells are stimulated with neurotransmitters, hormones, or growth factors. The released fatty acid can be metabolized in brain tissue by three enzymatic pathways--cyclooxygenase, lipoxygenase, and cytochrome P450--giving rise to a series of biologically active products, the eicosanoids. Intracellular actions of these lipids include regulation of membrane ion channels, protein kinases, and ion pumps, thus suggesting a role as neuronal second messengers. In addition, the eicosanoids may be released into the extracellular space and interact with high affinity, G protein-coupled receptors on neurons and glial cells. Acting through these two distinct and complementary modes of action, the eicosanoids may participate in several forms of neuromodulation and synaptic plasticity.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0892-0915
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
8
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
65-83
|
| pubmed:dateRevised |
2005-11-16
|
| pubmed:meshHeading | |
| pubmed:year |
1994
|
| pubmed:articleTitle |
Eicosanoids in synaptic transmission.
|
| pubmed:affiliation |
Unité de Neurobiologie et Pharmacologie, Institut National de la Santé et de la Recherche Médicale, Paris, France.
|
| pubmed:publicationType |
Journal Article,
Review
|