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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5-6
|
| pubmed:dateCreated |
1994-4-11
|
| pubmed:abstractText |
The frequency of RAS and p53 mutations was investigated in 30 acute promyelocytic leukemias by single strand conformation polymorphism analysis and direct sequencing of genomic DNA. Only two cases bore N-RAS codon 12 mutations and none had p53 mutations responsible for aminoacid substitutions. It would, therefore, seem that neither RAS nor p53 are involved in acute promyelocytic leukemogenesis.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
1042-8194
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
11
|
| pubmed:geneSymbol |
p53
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
405-10
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8124213-Base Sequence,
pubmed-meshheading:8124213-Genes, p53,
pubmed-meshheading:8124213-Genes, ras,
pubmed-meshheading:8124213-Humans,
pubmed-meshheading:8124213-Leukemia, Promyelocytic, Acute,
pubmed-meshheading:8124213-Molecular Sequence Data,
pubmed-meshheading:8124213-Mutation
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Frequency of RAS and p53 mutations in acute promyelocytic leukemias.
|
| pubmed:affiliation |
Istituto Clinica Medica I, University of Perugia, Italy.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|