Linked Life Data

8123724

Source:http://linkedlifedata.com/resource/pubmed/id/8123724

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11-12
pubmed:dateCreated
1994-4-14
pubmed:abstractText
Sprodiamide Injection (S-043 Injection, Nycomed Salutar; WIN 59080, Sterling Winthrop) is a magnetic susceptibility-based MRI contrast agent which contains 500 mM dysprosium diethylenetriaminepentaacetic acid bis(methylamide) (DyDTPA-BMA), and 25 mM caldiamide sodium (CaNaDTPA-BMA). A study was conducted to evaluate clearance of drug in cynomolgus monkeys. Eighteen cynomolgus monkeys, divided into three groups of six animals each, were administered Sprodiamide Injection intravenously at dose levels of 0.25, 0.5 and 2.5 mmol kg-1, respectively. The concentration of dysprosium in serum was determined in a monkey serum-hydrochloric acid matrix by inductively-coupled plasma atomic emission spectrometry (ICP-AES). The ICP-AES method was demonstrated to be valid for sensitivity, precision, accuracy, and specificity. The dynamic range was linear from 0 to 50 micrograms ml-1 and the limit of quantification was 24 ng ml-1. The measured dysprosium concentration in monkey serum ranged from 0 to 339 micrograms ml-1 for the 0.25 mmol kg-1 Sprodiamide Injection dose group, from 0 to 633 micrograms ml-1 for the 0.5 mmol kg-1 and from 0 to 2920 micrograms ml-1 for 2.5 mmol kg-1 dose groups. Dysprosium was not detected after 480 min in any of the serum samples from the 0.25 and 0.5 mmol kg-1 dose groups after the administration of Sprodiamide Injection. All the monkeys in the 2.5 mmol kg-1 dose group, with one exception, required 720 min for clearance of the drug from the serum. The drug was completely cleared from serum in all monkeys within 24 h.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0731-7085
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1129-34
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:articleTitle
Determination of dysprosium in monkey serum by inductively-coupled plasma atomic emission spectrometry (ICP-AES) after the administration of Sprodiamide Injection, a new contrast medium for magnetic resonance imaging.
pubmed:affiliation
Nycomed Salutar Inc., Sunnyvale, CA 94086.
pubmed:publicationType
Journal Article