Linked Life Data

8123574

Source:http://linkedlifedata.com/resource/pubmed/id/8123574

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1994-4-14
pubmed:abstractText
Etretinate and its metabolite acitretin have been shown to be highly effective in the treatment of various disorders of keratinization, including lamellar ichthyosis. The aim of the present study was to provide further information on acitretin dosage regimens in the management of lamellar ichthyosis. Seven patients with classical manifestations of lamellar ichthyosis participated in the study. Five patients improved markedly, and the remaining patients showed mild to moderate improvement. Two patients improved following gradual incremental increase in dosage (> or = 35 mg/day). Four patients, including a patient with the erythrodermic variant, required low-dose acitretin treatment (< or = 25 mg/day), as higher doses resulted in a marked deterioration in their skin condition. The dichotomy with respect to the response to acitretin suggests that lamellar ichthyosis is a spectrum of at least two conditions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0007-0963
pubmed:author
pubmed:issnType
Print
pubmed:volume
130
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
211-4
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Acitretin in the treatment of lamellar ichthyosis.
pubmed:affiliation
Department of Dermatology, University Hospital Nijmegen, The Netherlands.
pubmed:publicationType
Journal Article