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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1-2
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pubmed:dateCreated |
1994-4-4
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pubmed:abstractText |
The neuronal growth-associated protein (GAP-43) is widely expressed during embryonic growth and axonal regeneration and has been thought to contribute to synaptic plasticity in adult animals. In contrast to the exclusively presynaptic pattern of GAP-43 immunoreactivity in sympathetic ganglia, GAP-43 intensely and selectively labeled the noradrenergic subpopulation of adult rat adrenal medullary chromaffin cell bodies, a pattern which persisted with adrenal denervation. Adjacent adrenergic islands containing neuropeptide Y and phenylethanolamine-N-methyl transferase immunoreactivity failed to express GAP-43. The immunohistochemical appearance of GAP-43 was qualitatively unchanged in the adrenal medulla of aged and diabetic rats, conditions in which the sympathoadrenal axis is thought to be dysfunctional.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0304-3940
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
12
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pubmed:volume |
162
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
29-33
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:8121631-Adrenal Medulla,
pubmed-meshheading:8121631-Animals,
pubmed-meshheading:8121631-Axons,
pubmed-meshheading:8121631-Cold Temperature,
pubmed-meshheading:8121631-Denervation,
pubmed-meshheading:8121631-Enterochromaffin Cells,
pubmed-meshheading:8121631-GAP-43 Protein,
pubmed-meshheading:8121631-Ganglia, Sympathetic,
pubmed-meshheading:8121631-Immunohistochemistry,
pubmed-meshheading:8121631-Male,
pubmed-meshheading:8121631-Membrane Glycoproteins,
pubmed-meshheading:8121631-Nerve Regeneration,
pubmed-meshheading:8121631-Nerve Tissue Proteins,
pubmed-meshheading:8121631-Rats,
pubmed-meshheading:8121631-Rats, Sprague-Dawley,
pubmed-meshheading:8121631-Stress, Physiological,
pubmed-meshheading:8121631-Synapses
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pubmed:year |
1993
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pubmed:articleTitle |
Correlation of GAP-43 immunoreactivity with subpopulations of chromaffin cells in rat adrenal medulla.
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pubmed:affiliation |
Department of Pathology, Washington University School of Medicine, Saint Louis, MO 63110.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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