Linked Life Data

8121569

Source:http://linkedlifedata.com/resource/pubmed/id/8121569

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1994-4-7
pubmed:abstractText
In the vast majority of studies that address the role of surgery in the management of high-grade gliomas, the degree of tumor removal accomplished is solely based on the intraoperative perception of the neurosurgeon. Despite its fundamental importance for a comparison of different treatment modalities, little systematic effort has been made to evaluate the residual gross tumor by neuroimaging methods immediately after surgery. We report the results of a prospective study using contrast-enhanced computed tomography and magnetic resonance imaging (MRI) to monitor 60 patients after the resection of a high-grade glioma. In each case, the first scans were obtained between Days 1 and 5 after surgery, followed by serial imaging every 2 to 3 months, usually until the condition of the patient deteriorated severely or the patient died. Gadolinium-enhanced MRI proved to be extremely valuable for assessing gross residual tumor when performed during Days 1 to 3 after the resection of a preoperatively enhancing high-grade glioma. This timing avoided surgically induced contrast enhancement and minimized interpretative difficulties. In delineating residual tumor, MRI was vastly superior to computed tomography. About 80% of tumor "recurrences" emerged from definitely enhancing remnants, as revealed by early postoperative MRI. The neurosurgeon's estimation of gross tumor burden reduction could be shown to be much less accurate (by a factor of 3) than the postoperative assessment by modern neuroimaging. In our series, residual tumor enhancement was the most predictive prognostic factor of survival in patients with glioblastoma, followed by radiotherapy. Patients with a residual tumor postoperatively had a 6.595-times higher risk of death in comparison to patients without a residual tumor. Patients undergoing radiotherapy had a 0.258-times lower risk of death in comparison to patients who were not treated with radiation. Concerning survival, the prognostic significance of both variables surpassed age and performance.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0148-396X
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
45-60; discussion 60-1
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:8121569-Brain Neoplasms, pubmed-meshheading:8121569-Combined Modality Therapy, pubmed-meshheading:8121569-Contrast Media, pubmed-meshheading:8121569-Cranial Irradiation, pubmed-meshheading:8121569-Female, pubmed-meshheading:8121569-Follow-Up Studies, pubmed-meshheading:8121569-Gadolinium DTPA, pubmed-meshheading:8121569-Glioblastoma, pubmed-meshheading:8121569-Humans, pubmed-meshheading:8121569-Iohexol, pubmed-meshheading:8121569-Magnetic Resonance Imaging, pubmed-meshheading:8121569-Male, pubmed-meshheading:8121569-Middle Aged, pubmed-meshheading:8121569-Neoplasm Recurrence, Local, pubmed-meshheading:8121569-Organometallic Compounds, pubmed-meshheading:8121569-Pentetic Acid, pubmed-meshheading:8121569-Postoperative Complications, pubmed-meshheading:8121569-Prognosis, pubmed-meshheading:8121569-Prospective Studies, pubmed-meshheading:8121569-Survival Rate, pubmed-meshheading:8121569-Tomography, X-Ray Computed
pubmed:year
1994
pubmed:articleTitle
Early postoperative magnetic resonance imaging after resection of malignant glioma: objective evaluation of residual tumor and its influence on regrowth and prognosis.
pubmed:affiliation
Department of Neurosurgery, University of Heidelberg, Germany.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't