Linked Life Data

8120541

Source:http://linkedlifedata.com/resource/pubmed/id/8120541

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1994-4-7
pubmed:abstractText
This report concerns the study of synaptophysin (SP) expression in the anterior horn of three cases of lower motor neuron disease (L-MND). All patients studied had anterior horn cell degeneration without neuropathological evidence of corticospinal tract degeneration. Spinal cords from six patients with no neurological disease served as controls. Immunocytochemical techniques were used. The results show that in L-MND there is decreased SP immunoreactivity of the anterior horn neuropil, but preservation of immunoreactive dots around the cell body and proximal processes, and the presence of some residual neurons in the affected gray matter that are surrounded by a dense accumulation of immunoreaction products. These findings resemble those of classical amyotrophic lateral sclerosis (ALS), indicating similarities in the distribution patterns of presynaptic terminals in the anterior horn of L-MND and classical ALS.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0022-3069
pubmed:author
pubmed:issnType
Print
pubmed:volume
53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
196-201
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Immunocytochemical studies on synaptophysin in the anterior horn of lower motor neuron disease.
pubmed:affiliation
Department of Pathology, Montefiore Medical Center, Bronx, New York 10467.
pubmed:publicationType
Journal Article