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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1994-4-7
|
| pubmed:abstractText |
The M protein of Streptococcus pyogenes plays a major role in the virulence of these bacteria. Members of the M protein superfamily are characterized by the presence of tandem segments of repeated amino acid sequences. The NH2-terminal end of the M proteins is a hypervariable region that harbors the type-specific epitopes of the molecule. Pepsin cleaves the molecule into a highly conserved carboxyl terminal half and a variable amino terminal portion referred to as pep M. In some individuals, infection with certain serotypes of group A streptococci is followed by autoimmune disorders such as rheumatic fever and acute glomerulonephritis. The serotypes of M protein that show a high degree of association with acute rheumatic fever are referred to as rheumatogenic serotypes. We have reported that one such serotype, type 5, is a superantigen to human T cells, specifically stimulating T cells bearing V beta 2, V beta 4, and V beta 8 elements. Here we extend our studies by examining other rheumatogenic serotypes for superantigenic properties. Studies with types 6, 18, 19, and 24 M proteins revealed that they are all superantigens to human T cells. The specificity to V beta 4 was shared by the rheumatogenic M proteins tested; however, each pep M serotype has its unique characteristic set of V beta specificity and these are distinct from those reported for the streptococcal pyrogenic exotoxins. The non-rheumatogenic serotype, pep M2, only stimulated V beta 2-bearing T cells. This study establishes that the structurally related M proteins represent a family of streptococcal superantigens analogous to the structurally related family of staphylococcal enterotoxin superantigens.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Outer Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Exotoxins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...,
http://linkedlifedata.com/resource/pubmed/chemical/SpeA protein, Streptococcus pyogenes,
http://linkedlifedata.com/resource/pubmed/chemical/Superantigens,
http://linkedlifedata.com/resource/pubmed/chemical/erythrogenic toxin,
http://linkedlifedata.com/resource/pubmed/chemical/streptococcal M protein
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0022-1767
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
152
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2066-73
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:8120408-Amino Acid Sequence,
pubmed-meshheading:8120408-Antigens, Bacterial,
pubmed-meshheading:8120408-Bacterial Outer Membrane Proteins,
pubmed-meshheading:8120408-Bacterial Proteins,
pubmed-meshheading:8120408-Base Sequence,
pubmed-meshheading:8120408-Carrier Proteins,
pubmed-meshheading:8120408-Exotoxins,
pubmed-meshheading:8120408-Humans,
pubmed-meshheading:8120408-Lymphocyte Activation,
pubmed-meshheading:8120408-Membrane Proteins,
pubmed-meshheading:8120408-Molecular Sequence Data,
pubmed-meshheading:8120408-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:8120408-Rheumatic Fever,
pubmed-meshheading:8120408-Sensitivity and Specificity,
pubmed-meshheading:8120408-Sequence Alignment,
pubmed-meshheading:8120408-Streptococcus,
pubmed-meshheading:8120408-Superantigens,
pubmed-meshheading:8120408-T-Lymphocytes
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Characterization of unique human TCR V beta specificities for a family of streptococcal superantigens represented by rheumatogenic serotypes of M protein.
|
| pubmed:affiliation |
Veteran's Administration Medical Center, Memphis, TN 38104.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
|